中国中药杂志2026，Vol.51Issue(6)：1537-1544,8.DOI:10.19540/j.cnki.cjcmm.20251215.501
心阴虚理论视角下慢性心力衰竭致焦虑的病理机制与中医治疗策略研究进展
Research progress on pathological mechanism of anxiety induced by chronic heart failure and TCM treatment strategies from perspective of heart-Yin deficiency theory
摘要
Abstract
In the field of cardiovascular diseases,chronic heart failure(CHF),as an increasingly serious health challenge,is often intertwined with anxiety disorders,forming a complex clinical comorbidity.The incidence of anxiety gradually increases with the progression of heart failure,significantly reducing patients' quality of life and aggravating the overall disease burden.Modern medicine not only focuses on the pathophysiological mechanisms of CHF but has also gradually emphasized the bidirectional relationship between CHF and psychological states.The TCM theory of heart-Yin deficiency provides a distinctive theoretical perspective for elucidating the complex associations underlying such mind-body comorbidity and offers unique advantages in the treatment of CHF with comorbid anxiety.Based on the theory of heart-Yin deficiency,this article systematically explores the intrinsic pathological mechanisms by which CHF induces anxiety symptoms,as well as corresponding TCM treatment strategies.A pathogenic model is proposed in which heart-Yin deficiency leads to"failure to control deficiency fire,scorching the collaterals and disturbing the spirit","blood stasis with collateral damage,resulting in insufficient nourishment of the spirit and vessels",and"aggregation of phlegm,stasis,and toxins,causing concurrent impairment of the heart and spirit".This model elucidates the intrinsic associations with modern medical mechanisms such as neuroendocrine dysregulation,inflammatory and oxidative stress,and gut microbiota imbalance,highlighting the central role of heart-Yin deficiency in disease progression.With respect to treatment,guided by the principle of"nourishing Yin and calming the spirit",this article systematically analyzes the multiple effects of Chinese herbal compound prescriptions and acupuncture and moxibustion therapies in improving cardiac function and alleviating anxiety symptoms,aiming to provide a theoretical basis and practical guidance for the clinical management of anxiety in patients with CHF.关键词
心阴虚/慢性心力衰竭/焦虑/滋养心阴Key words
heart-Yin deficiency/chronic heart failure/anxiety/nourishing heart-Yin引用本文复制引用
胡书涵,倪世豪,杨忠奇,陈嘉慧,李思静,李姿儒,张小娇,何星灵,刘健红,廖慧丽,鲁路..心阴虚理论视角下慢性心力衰竭致焦虑的病理机制与中医治疗策略研究进展[J].中国中药杂志,2026,51(6):1537-1544,8.基金项目
国家自然科学基金项目(82374406,82205236) （82374406,82205236）
广州市重点研发计划项目(2024B03J1298) （2024B03J1298）
广东省中医药局科研项目(20241087,20241109) （20241087,20241109）
广州中医药大学第一附属医院中青年骨干人才培养项目([2023]186) （[2023]186）
杨忠奇省名中医传承工作室项目(粤中医办函[2023]108号) （粤中医办函[2023]108号）
广东省医学科学技术研究基金项目(B2025119) （B2025119）
广州中医药大学"固本"工程一级学科能力提升项目(GZY2025GB0104) （GZY2025GB0104）
广州中医药大学第一临床医学院2025年院级"揭榜挂帅"研究生创新能力提升项目(A3-0317-25-110-002) （A3-0317-25-110-002）
