中华临床免疫和变态反应杂志2026，Vol.20Issue(1)：43-48,6.DOI:10.3969/j.issn.1673-8705.2026.01.005
JAK抑制剂治疗大疱性表皮松解症2例并文献复习
Two cases of bullous epidermolysis bullosa treated with JAK inhibitors and literature review
尹婧 1凃璨 2姜琨 1张红梅 1陈金波1
作者信息
- 1. 430022 武汉,武汉市第一医院皮肤科
- 2. 430022 武汉,武汉市第一医院肾病内科
- 折叠
摘要
Abstract
Objective Currently,there is a lack of effective oral medication for epidermolysis bullosa(EB).This article reports cases of EB patients treated with JAK inhibitors in the Department of Dermatology,Wuhan No.1 Hospital,and summarizes clinical experience based on a review of the literature.Methods Clin-ical data and follow-up results of EB patients treated with JAK inhibitors in our hospital were retrospectively col-lected.A systematic search of domestic and international literature was conducted,and relevant studies were screened according to inclusion and exclusion criteria.Data from the literature and our cases were combined for comparative analysis.Results Two EB patients treated with JAK inhibitors in the Department of Dermatology,Wuhan No.1 Hospital,showed significant improvement in skin lesions and pruritus.The literature search iden-tified seven reports involving 18 EB patients treated with JAK inhibitors.In the combined analysis of 20 patients(including our two cases),19 achieved varying degrees of disease remission,including one with complete re-mission and 18 with partial remission.Conclusion JAK inhibitors can rapidly control EB symptoms and allevi-ate pruritus,with no serious adverse events reported to date.关键词
大疱性表皮松解症/JAK抑制剂Key words
epidermolysis bullosa/JAK inhibitors引用本文复制引用
尹婧,凃璨,姜琨,张红梅,陈金波..JAK抑制剂治疗大疱性表皮松解症2例并文献复习[J].中华临床免疫和变态反应杂志,2026,20(1):43-48,6.
