中国茶叶2026，Vol.48Issue(3)：26-37,12.
茶氨酸对中枢神经系统多层级调控作用的研究进展
Research Progress on the Multilevel Regulatory Effects of L-Theanine on the Central Nervous System
摘要
Abstract
L-Theanine is a unique amino acid abundant in tea leaves,it is characterized by its high biosafety and fa-vorable blood-brain barrier permeability.In recent years,research on L-theanine has expanded from its simple neu-roprotective effects to its multilevel regulatory roles in the intervention of neurodegenerative diseases and the modu-lation of emotions and behavior.Accumulating evidences indicate that L-theanine exerts beneficial effects in Al-zheimer's disease and Parkinson's disease models through multiple mechanisms,including regulation of neurotrans-mitter homeostasis,suppression of oxidative stress and neuroinflammation,improvement of mitochondrial function,enhancement of synaptic plasticity,and modulation of autophagy.In addition,L-theanine exhibits significant regula-tory effects on sleep quality,anxiety and depression,which are associated with glutamate-GABA balance,monoami-nergic neurotransmission,inhibition of the hypothalamic-pituitary-adrenal axis,and gut-brain axis modulation.This review systematically summarized the physicochemical properties,metabolic characteristics,and recent research progress of L-theanine in neurodegenerative disease intervention and neuroregulatory functions.The underlying mechanisms were comprehensively analyzed from the perspectives of neurotransmitter regulation,oxidative stress and inflammation,mitochondrial function,synaptic plasticity,and gut-brain axis interactions.Furthermore,current limitations and future research directions were discussed.关键词
茶氨酸/神经保护/阿尔茨海默病/帕金森病/抗焦虑/抗抑郁Key words
theanine/neuroprotection/Alzheimer's disease/Parkinson's disease/anti-anxiety/anti-depressant分类
农业科技引用本文复制引用
王佳童,戴伟东,林智..茶氨酸对中枢神经系统多层级调控作用的研究进展[J].中国茶叶,2026,48(3):26-37,12.基金项目
国家重点研发计划青年科学家项目(2023YFD1601700)、浙江省自然科学基金杰出青年项目(LR23C160002) （2023YFD1601700）
