中西医结合慢性病杂志2026，Vol.3Issue(2)：51-56,6.DOI:10.26950/j.issn.2097-5031.2026.02.009
姜黄素抗肝癌的多维探索:化学特征、分子机制与联合用药
Multidimensional Exploration of Curcumin in Hepatocellular Carcinoma Therapy:Chemical Characteristics,Molecular Mechanisms,and Combination Therapy
摘要
Abstract
Hepatocellular carcinoma(HCC)is a highly malignant tumor characterized by insidious onset,difficulties in early diagnosis,and high mortality rates,which seriously affects patients'quality of life and survival.Curcumin,a polyphenolic compound extracted from the rhizome of the traditional Chinese herb turmeric,is widely used in food processing and healthcare.In recent years,with increasing research on curcumin,its application in the treatment of HCC has attracted widespread attention.Curcumin can suppress inflammatory activity in liver cancer,induce apoptosis of hepatocellular carcinoma cells through multiple pathways,inhibit abnormal intratumoral angiogenesis,and demonstrate effective antiviral pharmacological effects against hepatitis virus.This review systematically summarizes recent advances in the research on curcumin against liver cancer,aiming to provide valuable references for basic research,drug development,and clinical applications of curcumin in the treatment of HCC.关键词
肝细胞癌/姜黄素/中药/炎症/细胞凋亡/血管生成Key words
hepatocellular carcinoma/curcumin/traditional Chinese medicine/inflammation/apoptosis/angiogenesis分类
医药卫生引用本文复制引用
高浩莱,宋元铭,陈尚祥,王哲..姜黄素抗肝癌的多维探索:化学特征、分子机制与联合用药[J].中西医结合慢性病杂志,2026,3(2):51-56,6.基金项目
国家自然科学基金地区科学基金项目(82460484) （82460484）
北京市希思科临床肿瘤学领航研究基金项目(Y-2019AZMS-0055) （Y-2019AZMS-0055）
