中医杂志2026，Vol.67Issue(5)：487-491,5.DOI:10.13288/j.11-2166/r.2026.05.005
"肝苦急"视角下有毒中药肝损伤的发病机制与配伍减毒策略探析
Mechanisms of Hepatotoxicity Induced by Toxic Chinese Herbal Medicinals and Compatibility-Based Detoxification Strategies from the Perspective of the"Liver Aversion to Acute Irritation"Theory
摘要
Abstract
This study establishes an integrated research paradigm based on traditional Chinese medicine(TCM)theory,guided by pathological characteristics,centered on formula compatibility principles,and supported by multi-disciplinary technologies,to systematically analyze the mechanisms of hepatotoxicity induced by toxic Chinese herbal medicinals and strategies for reducing toxicity through compatibility.The findings revealed that the pathomechanism aligns closely with the"liver aversion to acute irritation"theory from Inner Canon of Yellow Emperor(《黄帝内经》).The core pathology involves an imbalance between liver's form and function,which is characterized by malnourish-ment of liver form due to yin-blood depletion and dysfunction in ascending-dispersing and free-flowing activities,and closely linked to modern pathological mechanisms such as microcirculatory disturbances,oxidative stress,inflamma-tory response,metabolic disorder and gut-liver axis dysregulation.Based on this,a multi-layered compatibility strategy for toxicity reduction is put forward,which involves using sweet medicinals to alleviate urgency,balancing the liver form and its function,and pre-regulating other organs.This provides a theoretical basis for the safe application of toxic Chinese herbal medicinals.关键词
肝损伤/有毒中药/肝苦急/中药配伍/配伍减毒Key words
liver injury/toxic Chinese herbal medicinals/liver aversion to acute irritation/combination of Chinese herbal medicinals/toxicity reduction through herbal compatibility引用本文复制引用
李想,郭浏阳,俞志超,周学平.."肝苦急"视角下有毒中药肝损伤的发病机制与配伍减毒策略探析[J].中医杂志,2026,67(5):487-491,5.基金项目
国家自然科学基金(81973741) （81973741）
江苏省基础研究专项资金(自然科学基金)青年基金(BK20240732) （自然科学基金）
江苏省中医药科技发展计划(MS2023009) （MS2023009）
江苏省高等学校基础科学(自然科学)研究面上项目(23KJB360012) （自然科学）
