中医杂志2026，Vol.67Issue(5)：510-516,7.DOI:10.13288/j.11-2166/r.2026.05.009
中医脾胃病证候与病证结合动物模型研究现状及展望
Current Status and Prospective of Research on Disease-Syndrome Integrated Animal Models of Spleen and Stomach Diseases in Traditional Chinese Medicine
摘要
Abstract
Animal model research on spleen and stomach diseases in traditional Chinese medicine(TCM)is of great significance for elucidating the nature of diseases and syndromes and for revealing the mechanisms of action of Chinese herbal medicinals.At present,studies on classical TCM syndrome models of spleen and stomach diseases mainly focus on spleen deficiency syndrome,liver constraint syndrome,and damp-heat syndrome.Model construc-tion is mostly based on the etiological and pathophysiological characteristics of syndrome,and model evaluation primarily involves macroscopic manifestations and physicochemical indicators.This paper summarizes the current research status of animal models integrating disease and syndrome for seven common spleen and stomach diseases,including chronic gastritis and gastric precancerous lesions,gastroesophageal reflux disease,functional dyspepsia,inflammatory bowel disease,irritable bowel syndrome,functional constipation,and functional diarrhea.The model-ing methods and characteristics of disease-syndrome combined animal models for each disease are analyzed.It is pro-posed that future research on disease-syndrome integration in spleen and stomach diseases should move toward syste-matic,precise,and integrative development,and that interdisciplinary and cross-disciplinary research approaches should be adopted to enhance the predictive value and application efficiency of disease-syndrome combined animal models.关键词
脾胃病/动物模型/病证结合/证候Key words
spleen and stomach diseases/animal models/disease-syndrome integration/syndrome引用本文复制引用
张佳琪,付阳茜,王争,王凤云,唐旭东,方俐晖,温永天,刘珊,师卓,王忻彤,戴心怡,佘美龄,胡蓝烁..中医脾胃病证候与病证结合动物模型研究现状及展望[J].中医杂志,2026,67(5):510-516,7.基金项目
中国科学技术协会2024年中医脾胃病学学科发展研究(2024XKFZYJ) （2024XKFZYJ）
