中医杂志2026，Vol.67Issue(5)：517-522,6.DOI:10.13288/j.11-2166/r.2026.05.010
中医脾胃病脑肠互动原理的基础研究现状、问题及策略
Current Status,Challenges,and Strategies of Basic Research on the Brain-Gut Interaction Theory for Spleen and Stomach Diseases in Traditional Chinese Medicine
摘要
Abstract
The brain-gut interaction theory is a multidimensional integrative concept based on the brain-gut axis,involving neural,endocrine,and immune regulatory networks as well as the gut microbiota.Zangfu organs(脏腑)theory in traditional Chinese medicine(TCM)shows a high degree of consistency with the brain-gut interaction theory,and the core functions such as the spleen and stomach governing the ascending of the clear and descending of the turbid,the liver governing the free flow of qi,and the heart governing mental and emotional activities are closely asso-ciated with the multi-level regulatory mechanisms of the brain-gut axis.TCM therapy can modulate brain-gut interac-tions through multiple pathways in the treatment of spleen and stomach diseases,including the regulation of gastroin-testinal hormone secretion,neurotransmitter levels,the hypothalamic-pituitary-adrenal(HPA)axis,immune homeo-stasis and inflammatory responses,as well as the gut microecology.However,current basic research on the brain-gut interaction theory in TCM for spleen and stomach diseases still faces several challenges,such as difficulties in inte-grating TCM spleen-stomach theory with modern pathophysiology,lack of innovation in research concepts,and limita-tions in research methodologies.It is therefore proposed that multidisciplinary collaboration,multi-omics technologies,and targeted research approaches should be adopted to provide more comprehensive methods for basic research on TCM spleen and stomach diseases,thereby promoting the in-depth development of brain-gut interaction theory.关键词
脑肠互动/脑-肠轴/脾胃病/脏腑理论/脑肠肽/肠道微生物Key words
brain-gut interaction/brain-gut axis/spleen and stomach diseases/zang-fu organs(脏腑)theory/brain-gut peptides/gut microbiota引用本文复制引用
陈婷,朱进霞,侯晓华,张晓丽,郑丽飞,张磊,王新鑫,李璇,唐旭东..中医脾胃病脑肠互动原理的基础研究现状、问题及策略[J].中医杂志,2026,67(5):517-522,6.基金项目
国家重点研发计划青年科学家项目(2025YFC3511600) （2025YFC3511600）
国家自然科学基金(82474475,82074420) （82474475,82074420）
中国科学技术学会2024年中医脾胃病学学科发展研究(2024XKFZYJ) （2024XKFZYJ）
中华中医药学会青年培英计划(XH2025-058) （XH2025-058）
中国中医科学院优秀青年人才培养专项、达标专项(ZZ13-YQ-009、ZZ13-YQ-009-C1) （ZZ13-YQ-009、ZZ13-YQ-009-C1）
