巴楚医学2026，Vol.9Issue(1)：38-44,7.DOI:10.3969/j.issn.2096-6113.2026.01.004
不同分期子宫内膜异位症对体外受精-胚胎移植结局的影响
Influence of Endometriosis at Different Stages on the Outcome of In Vitro Fertilization-Embryo Transfer
摘要
Abstract
Objective:To investigate the effects of endometriosis(EMS)at different stages on the outcomes of in vitro fertilization/intracytoplasmic sperm injection(IVF/ICSI)-embryo transfer.Methods:A total of 579 patients who underwent IVF/ICSI-embryo transfer in Yichang Central People's Hospital from January 2015 to October 2023 were retrospectively analyzed.They were divided into four groups according to infertility factors:stage Ⅰ-Ⅱ EMS(n=32),Ⅲ-Ⅳ EMS(n=73),non-surgical EMS(n=72)and the tubal factor infertility group(n=402).The ovulation induction conditions,as well as the laboratory and clinical pregnancy-assisting outcomes between the groups were compared.Results:In the stage Ⅲ-Ⅳ EMS group,the GnRHa dosage[(5.38±3.70)mg]was higher than that of the tubal factor infertility group[(3.98±1.45)mg],stage Ⅰ-Ⅱ EMS group[(4.13±2.33)mg],and non-surgical EMS group[(4.51±2.98)mg](all P＜0.05),but there was no significant difference in gonadotropin dosage,estradiol level on the trigger day,number of dominant follicles(≥14 mm),and follicle output rate(all P＞0.05).Moreover,the number of eggs retrieved in stage Ⅲ-Ⅳ EMS group(8.99±4.62)was significantly lower than that of the tubal factor infertility group(11.40±5.73)and non-surgical EMS group(10.92±5.35)(both P＜0.05),but there was no significant difference in mature oocytes rate,two pronucleus rate and high-quality embryo rate(all P＞0.05).There was no significant difference in the clinical pregnancy rate of the first embryo transferation,the cumulative pregnancy rate and the live birth rate of a single ovulation induction cycle among groups(all P＞0.05).Conclusion:This study do not support that EMS at different stage has adverse effects on the embryo quality and clinical outcomes of IVF/ICSI.For stage Ⅲ-Ⅳ EMS,GnRHa ultra-long protocol may have benefits in IVF/ICSI.Although the number of retrieved oocytes in this group is lower than that in the the tubal factor infertility group,similar cumulative pregnancy rates and live birth rates can be achieved compared with other groups.关键词
子宫内膜异位症/体外受精/长方案/妊娠率Key words
endometriosis(EMS)/in vitro fertilization(IVF)/long protocol/pregnancy rate分类
医药卫生引用本文复制引用
祁晓晨,郑婷婷,李琴华,叶红..不同分期子宫内膜异位症对体外受精-胚胎移植结局的影响[J].巴楚医学,2026,9(1):38-44,7.基金项目
国家自然科学基金项目(82104589) （82104589）
