发育医学电子杂志2026，Vol.14Issue(2)：95-101,7.DOI:10.3969/j.issn.2095-5340.2026.02.003
呼吸道合胞病毒肺炎新生儿恢复期潮气肺功能特征分析
Analysis of tidal lung function characteristics in the recovery period of neonates with respiratory syncytial virus pneumonia
摘要
Abstract
Objective To explore the tidal lung function characteristics in the recovery period of neonates with respiratory syncytial virus pneumonia.Method A retrospective study was conducted on 96 neonates with community-acquired pneumonia who were admitted to the Affiliated Women's and Children's Hospital,School of Medicine,University of Electronic Science and Technology of China from November 2023 to February 2024.Based on the results of sputum nucleic acid testing within 48 h of admission,they were divided into RSV pneumonia group(n=48)and non-RSV pneumonia group(n=48).Children with RSV pneumonia were divided into preterm and full-term infants.Preterm infants with RSV pneumonia were further categorized into those with bronchopulmonary dysplasia(BPD)and those without BPD.The results of tidal lung function detection of the groups were compared during the recovery period.Statistical analysis was performed using the independent samples t-test and χ2 test.Results The time to peak tidal expiratory flow/total expiratory time(tPEF/tE)and volume to peak expiratory flow/expired tidal volume(VPEF/Vt)in the RSV pneumonia group were lower than those in the non-RSV pneumonia group[(33.79±10.58)%vs(39.29±10.79)%,(33.97±8.88)%vs(38.60±9.71)%,respectively;all P<0.05].In the RSV pneumonia group,the tPEF/tE and VPEF/Vt in preterm infants were lower than those in full-term infants[(24.99±6.15)%vs(32.31±8.83)%,(26.99±5.64)%vs(32.28±7.86)%,all P<0.05].Additionally,compared with preterm infants without BPD,the tPEF/tE and VPEF/Vt of preterm infants with RSV pneumonia and BPD during the recovery period were significantly lower[(27.16±1.64)%vs(20.30±2.66)%,(28.64±5.78)%vs(23.42±2.01)%,all P<0.05].Conclusion Neonates with RSV pneumonia,particularly preterm infants and those with BPD,face an increased likelihood of obstructive ventilatory dysfunction during the recovery period compared to neonates with non-RSV pneumonia.Clinicians should reinforce pulmonary function testing and long-term follow-up for neonates with RSV pneumonia,especially for preterm infants and children with BPD.关键词
呼吸道合胞病毒/新生儿/肺炎/肺功能/气道阻力Key words
Respiratory syncytial virus/Neonate/Pneumonia/Lung function/Airway resistance引用本文复制引用
杜维纳,高淑强,张小龙,林利苹,巨容..呼吸道合胞病毒肺炎新生儿恢复期潮气肺功能特征分析[J].发育医学电子杂志,2026,14(2):95-101,7.基金项目
四川省科技计划项目(2022YFS0241) （2022YFS0241）
