发光学报2026，Vol.47Issue(3)：400-413,14.DOI:10.37188/CJL.20250298
适配体夹心免疫传感器在生物检测中的应用
Application of Aptamer-based Sandwich Immunosensors in Bioanalysis
摘要
Abstract
Aptamer-based sandwich immunosensors are an emerging analytical platform that combines the high specificity recognition of aptamers with the high sensitivity of immunoassays.Due to their advantages of excellent selectivity and low detection limits,these biosensors hold great potential for use in bioanalytical applications.This review outlines the key strategies underlying such biosensors,including aptamer selection,sandwich structure con-struction,and nanomaterial-enhanced signal amplification,and surveys recent advances in their bioanalytical appli-cation for the detection of small molecules,proteins,and pathogenic microorganisms.Current challenges and prom-ising future directions for the field are also discussed.关键词
适配体/纳米材料/夹心免疫传感器/生物检测Key words
aptamer/nanomaterials/sandwich immunosensor/bioanalysis分类
数理科学引用本文复制引用
刘梅青,张云..适配体夹心免疫传感器在生物检测中的应用[J].发光学报,2026,47(3):400-413,14.基金项目
福建省自然科学基金(2024J08103) （2024J08103）
厦门市自然科学基金(3502Z202371032) （3502Z202371032）
国家自然科学基金(62505321)Supported by Fujian Provincial Natural Science Foundation(2024J08103) （62505321）
Natural Science Foundation of Xiamen(3502Z202371032) （3502Z202371032）
National Natural Science Foundation of China(62505321) （62505321）
