西部中医药2026，Vol.39Issue(3)：18-21,4.DOI:10.12174/j.issn.2096-9600.2026.03.04
季节变化对CUMS模型动物肝脏BSEP基因mRNA表达的影响
Influences of Seasonal Changes on BSEP Gene mRNA Expressions in the Liver of CUMS Animal Models
摘要
Abstract
Objective:To observe the influences of seasonal changes on bile salt export pump(BSEP)gene mRNA expressions in the liver of CUMS animal models.Methods:Healthy male Sprague-Dawley(SD)rats were purchased one week before the vernal equinox,summer solstice,autumnal equinox,and winter solstice,respectively,and they were randomized into the normal group and CUMS model group.CUMS method was adopted to construct animal models of liver failing to govern free coursing,TaqMan real-time quantitative PCR was applied to detect the levels of BSEP gene mRNA in liver,and to analyze the trends.Results:Compared with the normal group in the same season,CUMS group exhibits the elevated expressions of BSEP gene mRNA in liver;BSEP gene mRNA expressions in liver of the rats from all groups in autumn were lower than these in spring remarkably.Conclusion:The expressions of BSEP gene reveal seasonal changes,and the changes may be related to liver governing free coursing.关键词
肝主疏泄/慢性轻度不可预见性应激/四时五脏阴阳/胆酸盐输出泵基因Key words
liver governs free coursing/CUMS/four seasons,five viscera,Yin and Yang/BSEP分类
医药卫生引用本文复制引用
倪祥惠,吴菁,郭正阳,林川烘..季节变化对CUMS模型动物肝脏BSEP基因mRNA表达的影响[J].西部中医药,2026,39(3):18-21,4.基金项目
国家自然科学基金(81160418). （81160418）
