中医学报2026，Vol.41Issue(4)：799-806,8.DOI:10.16368/j.issn.1674-8999.2026.04.119
中医药调控PI3K/AKT信号通路治疗糖尿病脑病的研究进展
Research Progress on Traditional Chinese Medicine Treatment of Diabetic Encephalopathy by Regulating PI3K/Akt Signaling Pathway
摘要
Abstract
The phosphatidylinositol 3-kinase/protein kinase B(PI3K/Akt)signaling pathway is a classical pathway of cellular metab-olism.It participates in the occurrence and development of diabetic encephalopathy(DE)by regulating inflammation,oxidative stress,apoptosis,synaptic plasticity,amyloid β-protein(Aβ)deposition,and Tau protein hyperphosphorylation.Monomer of Chinese tradi-tional herbs and active ingredients from traditional Chinese medicine(TCM)(such as polysaccharides and glycosides)and TCM for-mulas(such as Qiwei Baizhu San and Buyang Huanwu Decoction)can alleviate neuroinflammation,counteract oxidative stress,and in-hibit apoptosis by activating the PI3K/Akt pathway,thereby effectively improving cognitive impairment in DE.However,related research still has limitations:mechanistically,studies mainly focus on the activity of the PI3K/Akt signaling pathway,and the regulatory mecha-nisms of TCM have not been fully clarified;much research remains at the cellular and animal experimental stages,with a lack of clinical safety and efficacy verification;interventions are primarily based on monomer of Chinese traditional herbs and compound formula,with fewer studies on TCM patent medicines and external therapies targeting this pathway.Due to the complexity of TCM components and the diversity of their targets,future studies should further explore the specific mechanisms by which TCM regulates the PI3K/Akt pathway,providing evidence-based guidance for the prevention and treatment of diabetic encephalopathy with TCM.关键词
糖尿病脑病/PI3K/AKT信号通路/中医药/中药单体/中药复方/认知障碍Key words
diabetic encephalopathy/PI3K/Akt signaling pathway/traditional Chinese medicine/monomer of Chinese traditional herb/TCM compound formula/cognitive impairment分类
医药卫生引用本文复制引用
代晓鸽,杨俊红..中医药调控PI3K/AKT信号通路治疗糖尿病脑病的研究进展[J].中医学报,2026,41(4):799-806,8.基金项目
河南省重点研发与推广专项科技攻关项目(232102311196) （232102311196）
2023 年度河南省中医学"双一流"创建科学研究专项课题项目(HSRP-DFCTCM-2023-1-27) （HSRP-DFCTCM-2023-1-27）
