感染、炎症、修复2026，Vol.27Issue(1)：57-61,5.DOI:10.3969/j.issn.1672-8521.2026.01.009
主乳管切除联合扩大切除手术对肉芽肿性小叶性乳腺炎患者治疗效果和复发率及预后的影响
Effects of major duct excision combined with extended resection on treatment outcome,recurrence rate and prognosis in patients with granulomatous lobular mastitis
摘要
Abstract
Objective To explore the effects of major duct excision combined with extended resection on treatment outcomes,recurrence rate and prognosis in patients with granulomatous lobular mastitis(GLM).Methods A total of 198 patients with GLM admitted to the Department of Breast Surgery of Zhengzhou People's Hospital from April 2020 to April 2024 were prospectively enrolled.Based on their disease severity and personal preferences,patients were assigned to one of three surgical groups:lesion resection alone(control group,n=66),extended resection alone(extended resection group,n=65),or major duct excision combined with extended resection(combined group,n=67).All patients were followed up for 12 months postoperatively via outpatient visits or telephone interviews.Treatment outcomes,breast cosmetic scores,and patient satisfaction were assessed at 6 months of follow-up,while recurrence and complication rates were evaluated at 12 months of follow-up.Results The overall response rate was significantly higher in the combined group(95.52%,64/67)and the extended resection group(83.08%,54/65)than that in the control group(68.18%,45/66),and was also significantly higher in the combined group than that in the extended resection group(χ2=17.117,P<0.001).The overall satisfaction rate in the combined group(94.03%,63/67)and the extended resection group(92.31%,60/65)was significantly higher than that in the control group(80.30%,53/66)(χ2=7.488,P=0.024);however,no significant difference was observed between the combined group and the extended resection group(P>0.05).At 12 months postoperatively,the recurrence rate was significantly lower in the combined group(1.49%,1/67)and the extended resection group(9.23%,6/65)than in the control group(22.73%,15/66),and was also significantly lower in the combined group than in the extended resection group(χ2=15.526,P<0.001).The overall incidence of surgery-related complications did not differ significantly among the three groups(P>0.05).Conclusions Major duct excision combined with extended resection significantly improves treatment outcomes and reduces the risk of recurrence within 12 months postoperatively in patients with GLM.However,it does not significantly influence breast cosmesis or patient satisfaction,nor does it markedly increase surgeryrelated complications.关键词
肉芽肿性小叶性乳腺炎/主乳管切除术/扩大切除手术/单纯病灶切除术Key words
granulomatous lobular mastitis/major duct resection/extended resection/lesion resection alone引用本文复制引用
叶贝贝,牛冰,冯燕枝,李庆辉..主乳管切除联合扩大切除手术对肉芽肿性小叶性乳腺炎患者治疗效果和复发率及预后的影响[J].感染、炎症、修复,2026,27(1):57-61,5.基金项目
河南省医学科技攻关计划联合共建项目(LHGJ20220784) （LHGJ20220784）
