海南医科大学学报2026，Vol.32Issue(6)：470-480,11.DOI:10.13210/j.cnki.jhmu.20250825.001
NETs在ALI/ARDS病理生理中的作用
The role of NETs in ALI/ARDS pathophysiology
摘要
Abstract
Acute lung injury(ALI)/Acute respiratory distress syndrome(ARDS)is an inflammatory lung disease with high morbidity and mortality,and its diagnosis and treatment is still an important challenge worldwide.Neutrophil aggregation and infil-tration play a key role in the development of this disease,and it is currently believed that neutrophils release neutrophil extracellu-lar traps(NETs)as one of the important mechanisms affecting the disease.In this paper,we will review the effects of NETs on pulmonary vascular endothelial cells,alveolar epithelial cells,coagulation function and the interaction relationship with immune cells during the pathophysiological process of ALI/ARDS,and discuss the strategy of targeting NETs to treat acute lung injury and the challenges of clinical translation,with the aim of providing new ideas for the diagnosis and treatment of this disease.关键词
中性粒细胞外捕网(NETs)/急性肺损伤(ALI)/急性呼吸窘迫综合征(ARDS)/炎症/免疫/肺泡上皮细胞/肺血管内皮细胞/凝血Key words
neutrophil extracellular traps(NETs)/Acute lung injury(ALI)/acute respiratory distress syndrome(ARDS)/In-flammation/Immunity/Alveolar epithelial cells/Pulmonary vascular endothelial cell/Coagulation分类
医药卫生引用本文复制引用
张文星,唐雯,李政玉,鲁俊才,李兆,彭继超,姚津剑,刘笑然..NETs在ALI/ARDS病理生理中的作用[J].海南医科大学学报,2026,32(6):470-480,11.基金项目
This study was supported by the National Natural Science Foundation of China(81960351 （）
82360379) （）
Hainan Provincial Natural Science Foundation High-level Talent Project(822RC835) 国家自然科学基金(81960351 （822RC835）
82360379) （）
海南省自然科学基金高层次人才项目(822RC835) （822RC835）
