河南中医2026，Vol.46Issue(4)：537-545,9.DOI:10.16367/j.issn.1003-5028.2026.04.0088
中医药调控炎症因子治疗放射性肠炎研究进展
Research Progress on Traditional Chinese Medicine in Regulating Inflammatory Factors for the Treatment of Radiation Enteritis
摘要
Abstract
Radiation enteritis(RE)is a severe intestinal complication resulting from radiotherapy in patients with pelvic,abdominal,or retroperitoneal malignancies.The imbalance between pro-inflammatory and anti-inflammatory factors,along with the cascade of inflam-matory mediators,constitutes the core pathological link in the onset of RE.This paper has systematically reviewed recent research pro-gress on the intervention of RE by TCM through the regulation of inflammatory factors.It has revealed that TCM monomers and com-pound formulas can mitigate intestinal inflammation,repair barrier function,and inhibit cell apoptosis through multiple effects,such as regulating the inflammatory factor network and related signaling pathways(e.g.,NF-κB,NLRP3,MAPK).This demonstrates the u-nique advantages of multi-target action and holistic regulation,indicating promising potential for clinical application.However,this field still faces the following challenges:(1)The analysis of pharmacodynamic mechanisms is not sufficiently precise,with inadequate in-depth research on the direct targets of drug action(e.g.,receptors,kinases),the specific processes of signal transduction,and the syn-ergistic mechanisms underlying the"sovereign-minister-assistant-courier"principle within compound formulas;(2)Research predomi-nantly focuses on single pathways,failing to systematically elucidate the holistic regulatory role of TCM in the synergy or antagonism a-mong multiple pathways;(3)Research is primarily centered on the verification of traditional formulas,with limited research on new compound formulas,new compatibilities,and innovative intestinal-specific dosage forms.Therefore,future research could employ tech-nologies such as molecular docking,gene editing,and proteomics,etc.to precisely identify direct action targets and elucidate the syner-gistic mechanisms of compound formula components.Furthermore,integrating multi-omics approaches with network pharmacology meth-ods to construct systematic regulatory networks is crucial,with a focus on exploring the synergistic patterns of TCM in regulating multiple inflammatory pathways.Leveraging novel models like organoids and organs-on-chips,etc.will be key to strengthening the innovative de-velopment and translational research of new Chinese medicinals,novel dosage forms,and new drug delivery systems.关键词
放射性肠炎/炎症因子/NF-κB信号通路/NLRP3信号通路/MAPK信号通路/痛泻要方/葛根芩连汤/白头翁汤/芍药汤/参苓白术散分类
医药卫生引用本文复制引用
朱巽娴,郑东林,吴发胜,奚文婷,王奡,周嘉雪,李丽芳,周李琳..中医药调控炎症因子治疗放射性肠炎研究进展[J].河南中医,2026,46(4):537-545,9.基金项目
广西壮族自治区(青年)岐黄学者培养项目(GXQH202422) （青年）
广西壮族自治区中医药适宜技术开发与推广项目(GZSY2024041) （GZSY2024041）
