杭州师范大学学报（自然科学版）2026，Vol.25Issue(2)：120-127,144,9.DOI:10.19926/j.cnki.issn.1674-232X.2025.02.141
犹素化修饰在内质网功能调控中的作用机制研究
Research on the mechanism of UFMylation in regulating endoplasmic reticulum function
摘要
Abstract
The endoplasmic reticulum(ER)is responsible for crucial functions such as protein synthesis,transport,folding,lipid and steroid synthesis,carbohydrate metabolism,and calcium storage.Its function is constantly monitored by multiple quality control mechanisms,including ER-phagy,ER-associated degradation(ERAD),and unfolded protein response(UPR).The ubiquitin-like modification is a typical form of post-translational modification essential for maintaining ER homeostasis.Ubiquitin-fold modifier 1(UFM1)covalently conjugates with intracellular proteins through UFMylation,analogous to ubiquitination.The UFMylation system primarily comprises UFM1,UBA5,UFC1,UFL1,and DDRGK1.UFMylation plays a critical role in ER stress,ERAD,selective autophagy,and endoplasmic reticulum-associated ribosome quality control(ER-RQC).关键词
犹素化修饰/内质网应激/内质网自噬/内质网相关核糖体质量控制Key words
UFMylation/endoplasmic reticulum stress/ER-phagy/endoplasmic reticulum-associated ribosome quality control分类
生物科学引用本文复制引用
万飘飘,赵新,艾易,郑康..犹素化修饰在内质网功能调控中的作用机制研究[J].杭州师范大学学报（自然科学版）,2026,25(2):120-127,144,9.基金项目
国家自然科学基金项目(32371022) （32371022）
浙江省基础公益研究计划项目(LY22C090002) （LY22C090002）
