中国中老年人群抑郁症状与胃肠道疾病风险的关联:一项基于CHARLS的横断面与纵向研究
Association between depressive symptoms and risk of gastrointestinal diseases in middle-aged and older Chinese adults:a cross-sectional and longitudinal study based on CHARLS
摘要
Abstract
Objective To evaluate the cross-sectional and longitudinal associations between depressive symptoms and gastrointestinal diseases(GID)among middle-aged and older adults in China.Methods Based on data from the China Health and Retirement Longitudinal Study(CHARLS,2011-2018),a study integrating cross-sectional and longitudinal design was conducted.The cross-sectional analysis included 15,014 participants aged≥45 years.For the longitudinal analysis,8154 participants without GID at baseline were followed until 2018.Multivariable logistic regression was employed to examine the cross-sectional association between Center for Epidemiologic Studies Depression Scale(CES-D)scores and GID.Multivariable Cox proportional hazards regression models,Kaplan-Meier curves,restricted cubic spline(RCS),and subgroup analyses were used to assess the longitudinal association between baseline depressive symptoms and incident GID.Sensitivity analyses were performed to validate the robustness of the results.Results Multivariable logistic regression revealed that each 1-point increase in CES-D score was associated with a 6%higher risk of GID(OR=1.06,95%CI 1.05-1.07).Compared with participants having no/mild depressive symptoms,those with moderate and severe symptoms had 76%higher risk(OR=1.76,95%CI 1.61-1.92)and a 1.40-fold higher risk(OR=2.40,95%CI 2.08-2.78)of GID,respectively.During follow-up,1881 participants(23.1%)were newly diagnosed with GID.Multivariable Cox regression showed that each 1-point increase in the severity of depressive symptoms score was associated with a 4%increase in GID risk(HR=1.04,95%CI 1.02-1.05).RCS analysis indicated a nonlinear dose-response relationship between depressive symptoms and GID risk(P for overall association<0.001,P for nonlinearity=0.009).Subgroup analyses demonstrated consistent associations across subgroups(P for interaction>0.05).Sensitivity analyses showed that participants in the highest quartile(Q4)of CES-D scores had an 84%higher risk of GID(HR=1.84,95%CI 1.58-2.16)compared with those in the lowest quartile(Q1).Conclusion Elevated depressive symptoms are associated with an increased risk of GID in middle-aged and older Chinese adults.关键词
抑郁症状/胃肠道疾病/中老年人群/中国健康与养老追踪调查Key words
depressive symptoms/gastrointestinal diseases/middle-aged and older adults/China Health and Retirement Longitudinal Study分类
医药卫生引用本文复制引用
田菁,肖准,黄一鸣,赵小诺,陈田田,王丽欣,马素平..中国中老年人群抑郁症状与胃肠道疾病风险的关联:一项基于CHARLS的横断面与纵向研究[J].解放军医学杂志,2026,51(2):188-195,8.基金项目
This work was supported by the National Natural Science Foundation of China Youth Program(82104772),the China Postdoctoral Science Foundation(2022M721067),the Henan Provincial Science and Technology Tackling Program(222102310502),the Henan Provincial Union Fund for Science and Technology Research and Development Plan(222301420062),the Henan Provincial Special Project of Scientific Research on Traditional Chinese Medicine(2022ZY2008),the Scientific Research Project for the"Double First-Class"Creation of Traditional Chinese Medicine in Henan Province(HSRP-DFCTCM-2023-3-20),and the Second Batch of Discipline Construction Projects for Henan Provincial Characteristic Key Disciplines of Traditional Chinese Medicine(STG-ZYX02-202109) 国家自然科学基金青年基金(82104772) （82104772）
中国博士后科学基金(2022M721067) （2022M721067）
河南省科技攻关计划(222102310502) （222102310502）
河南省科技研发计划联合基金(222301420062) （222301420062）
河南省中医药科学研究专项(2022ZY2008) （2022ZY2008）
河南省中医学"双一流"创建科学研究专项课题(HSRP-DFCTCM-2023-3-20) （HSRP-DFCTCM-2023-3-20）
河南省特色骨干学科中医学第二批学科建设项目(STG-ZYX02-202109) （STG-ZYX02-202109）
