李佳兴 1马超 1刘款 1王万超 1田园 1吴寿岭 2陈朔华 2董智刚 1刘四清1
作者信息
- 1. 华北理工大学附属医院肝胆胰外科一科,河北 唐山 063000
- 2. 华北理工大学附属开滦总医院健康保障中心,河北 唐山 063000
- 折叠
摘要
Abstract
Objective To investigate the relationship between the Chinese visceral adiposity index(CVAI)and the risk of digestive system malignant tumors based on the Kailuan cohort.Methods A prospective cohort study was conducted,and a total of 101,510 participants who underwent the Kailuan health examination in 2006 were included.After excluding individuals with a history of baseline cancer,missing CVAI data and related covariates,94 926 participants were finally included.Participants were categorized into 4 groups based on CVAI quartiles:Q1 group(CVAI<63.62,n=23 732),Q2 group(63.62≤CVAI<91.83,n=23 733),Q3 group(91.83≤CVAI<118.31,n=23 731),and Q4 group(CVAI≥118.31,n=23 730).A multivariate Cox proportional hazards regression model was used to analyze the impact of different CVAI values on the risk of digestive system malignant tumors.Subgroup analyses were performed according to participants'age,gender,body mass index(BMI),smoking status,and alcohol consumption status.Sensitivity analyses were conducted by excluding participants who developed digestive system malignant tumors within 1 year of follow-up and those taking lipid-lowering medications,respectively.Results Among the 94 926 participants,75 748 were male(79.8%)and 19 178 were female(20.2%).The median follow-up duration was(14.1±2.7)years.By the end of the study,2029 new cases of digestive system malignant tumors were identified.The incidence densities of digestive system malignant tumors in Q1-Q4 groups were 1.11,1.38,1.67,and 1.90 per 1000 person-years,respectively.After adjusting for relevant covariates,compared with Q1 group,the risk of digestive system malignant tumors in Q2 group(HR=1.15,95%CI 1.02-1.31),Q3 group(HR=1.35,95%CI 1.18-1.54),and Q4 group(HR=1.52,95%CI 1.33-1.73)was significantly increased.Conclusion A high CVAI value is positively correlated with the risk of digestive system malignant tumors.关键词
中国内脏脂肪指数/消化系统恶性肿瘤/肥胖/内脏脂肪Key words
Chinese visceral adiposity index/digestive system malignant tumor/obesity/visceral fat分类
医药卫生
