实用临床医药杂志2026，Vol.30Issue(4)：72-77,84,7.DOI:10.7619/jcmp.20257110
动态监测血清高迁移率族蛋白B1、葡萄糖调节蛋白78水平预测脓毒症患者预后的价值
Value of dynamic monitoring serum high mobility group box-1 and glucose-regulated protein 78 level in predicting the prognosis of sepsis patients
摘要
Abstract
Objective To investigate the value of dynamic monitoring serum high mobility group box-1(HMGB1)and glucose-regulated protein 78(GRP78)levels in predicting the prognosis of sep-sis patients.Methods A total of 208 sepsis patients were selected as the study subjects.Based on the 28-day survival outcomes,the patients were divided into good prognosis group and poor prognosis group.General data,serum HMGB1 and GRP78 levels were compared between the two groups.Logis-tic regression analysis was used to screen for the influencing factors of the prognosis of sepsis patients.Receiver operating characteristic(ROC)curves were plotted to analyze the predictive value of serum HMGB1 and GRP78 levels for patient prognosis.Results On the 0th,3rd and 7th days of admission,the Acute Physiology and Chronic Health Evaluation Ⅱ(APACHE Ⅱ)scores,as well as serum HMGB1 and GRP78 levels were higher in the poor prognosis group than those in the good prognosis group,with statistically significant differences(P＜0.05 or P＜0.001).On the 0th,3rd and 7th days of admission,HMGB1 and GRP78 were positively correlated with the APACHE Ⅱ score(P＜0.05).On day 0 of admission,serum HMGB1 and GRP78 levels,as well as the APACHE Ⅱ score,were all influencing factors for the prognosis of sepsis patients(P＜0.05).On the 0th,3rd and 7th days of admission,the area under the curve(AUC)values for predicting poor prognosis in sepsis patients using the combination of HMGB1 and GRP78 were 0.901,0.819 and 0.782,respectively,with the highest predictive AUC on day 0 of admission(P＜0.05).Conclusion HMGB1 and GRP78 are independent influencing factors for poor prognosis in sepsis patients.Dynamic monitoring of their levels is of clinical significance,with the highest predictive value on day 0 of admission,which can serve as an important auxiliary reference for early identification of high-risk sepsis patients.关键词
脓毒症/预后/高迁移率族蛋白B1/葡萄糖调节蛋白78/急性生理学与慢性健康状况评分系统Ⅱ/预测价值/受试者工作特征曲线/影响因素Key words
sepsis/prognosis/high mobility group box-1/glucose-regulated protein 78/Acute Physiology and Chronic Health Evaluation Ⅱ/predictive value/receiver operating characteristic curve/influencing factors分类
医药卫生引用本文复制引用
诸靖,张烨,王鹏..动态监测血清高迁移率族蛋白B1、葡萄糖调节蛋白78水平预测脓毒症患者预后的价值[J].实用临床医药杂志,2026,30(4):72-77,84,7.基金项目
江苏省自然科学基金项目(BK20221203) （BK20221203）
