低氧环境下的口腔稳态失衡
Oral homeostasis imbalance under hypoxia
摘要
Abstract
Hypoxia disrupts oral homeostasis through multiple interconnected pathways,including interference with tooth germ development,impairment of salivary gland function and salivary buffering capacity,compromise of the oral mucosal barrier,imbalance in jawbone and alveo-lar bone remodeling,and alterations in the diversity and functionality of the oral microbiome.These disturbances collectively contribute to the onset and progression of oral diseases.Moreover,disruption of oral homeostasis may,in turn,affect systemic homeostasis,increasing the risk of disorders in other organ systems through mecha-nisms involving inflammatory mediator release and microbial translocation.Here,we systematically review the effects and underlying mechanisms of hypoxia exposure on oral homeostasis,and further explore the interconnections between hypoxia-induced oral dysregulation and systemic homeostatic imbalance.This review aims to provide a comprehensive understanding of the regulatory networks linking oral and systemic homeostasis under hypoxia,thereby offering potential insights for maintaining homeostatic balance.关键词
低氧/口腔稳态/唾液腺/口腔黏膜屏障/颌骨/口腔微生物群/全身稳态Key words
hypoxia/oral homeostasis/salivary gland/oral mucosal barrier/jawbone/oral microbiome/systemic homeostasis分类
医药卫生引用本文复制引用
徐一帆,王松灵,周建..低氧环境下的口腔稳态失衡[J].华西口腔医学杂志,2026,44(2):215-223,9.基金项目
Beijing Municipal Government Grant(Beijing Laboratory of Oral Health,PXM2021_014226_000041) （Beijing Laboratory of Oral Health,PXM2021_014226_000041）
Natio-nal Natural Science Foundation of China(81741106,82470961) （81741106,82470961）
Beijing High-Level Innovation and Entrepreneurship Talent Support Program Leading Talent Projects(G202512061) （G202512061）
Projeot of Laboratory for Clinical Medicine(Capital Medical Uni-versity)[(2023)175] （Capital Medical Uni-versity）
Young Scientist Program of Beijing Stomatological Hospital,Capital Medical University(YSP202408) 北京市政府资助项目(口腔健康北京实验室,PXM20 21_014226_000041) （YSP202408）
国家自然科学基金(81741106,82470961) （81741106,82470961）
北京高层次创新创业人才支持计划领军人才项目(G202512061) （G202512061）
首都医科大学硝酸盐维持低氧稳态机制及转化应用基础临床联合实验室资助项目[(2023)175] （2023）
首都医科大学附属北京口腔医院青年科技创新人才培育计划(YSP202408) （YSP202408）
