华西口腔医学杂志2026，Vol.44Issue(2)：232-239,8.DOI:10.7518/hxkq.2026.2025350
基于气相色谱-质谱技术对复合树脂牙科材料的安全性研究
Safety study of resin-based dental materials using gas chromatography-mass spectrometry techniques
李钰洁 1曾沂涌 1杜振霞 1任桂芳2
作者信息
- 1. 北京化工大学化学学院,北京 100029
- 2. 北京市和平里医院口腔科,北京 100013
- 折叠
摘要
Abstract
Objective To investigate the clinical application safety of dental adhesives and composite resin-based dental materials.Methods A non-targeted screening of migrants from clinically used dentin adhesives and composite resin materials was conducted using gas chromatography-mass spectrometry(GC-MS).Migration media included saliva simulants with pH of 5.5,6.2,7.4,and 8.0,50%ethanol solution,and ultrapure water.By simulating migration under va-rious oral environments,six migrants were detected in the migration media.GC-MS/flame ionization detector was used for quantitative analysis of these migrants,and risk assessment was performed by combining their toxicity data.Results In all six migration media,the exposure levels of monomers and photoinitiators released from four commercially avai-lable resin-based dental materials were all within established safety thresholds.Conclusion This study conducted non-targeted detection and safety assessment of migrants from dental restorative materials.The exposure levels of all detected compounds were below safety limits,providing scientific evidence supporting the clinical safety of composite resin-based dental materials.关键词
复合树脂牙科材料/气相色谱-质谱/迁移物/风险评估Key words
resin-based dental materials/gas chromatography-mass spectrometry/migrations/risk assessment分类
医药卫生引用本文复制引用
李钰洁,曾沂涌,杜振霞,任桂芳..基于气相色谱-质谱技术对复合树脂牙科材料的安全性研究[J].华西口腔医学杂志,2026,44(2):232-239,8.
