老年医学与保健2026，Vol.32Issue(1)：32-37,6.DOI:10.3969/j.issn.1008-8296.2026.01.008
血清降钙素原、心肌肌钙蛋白Ⅰ和胆碱酯酶的表达与老年慢性心力衰竭合并肺部感染患者病情及预后的相关性分析
Association of serum procalcitonin,cardiac troponin Ⅰ,and cholinesterase with disease severity and prognosis in elderly patients with chronic heart failure and pulmonary infection
摘要
Abstract
Objective To explore the correlation between serum procalcitonin(PCT),cardiac troponin Ⅰ(cTnⅠ),and cholinesterase(ChE)expression and clinical status,prognosis in elderly patients with chronic heart failure(CHF)complicated by pulmonary infection(PI).Methods Clinical data were collected from 224 elderly patients with CHF complicated by PI who received treatment in the Third Hospital of Shijiazhuang from July 2023 to July 2024,serving as the study group.These patients were categorized into mild(n=71),moderate(n=98),and severe(n=55)groups based on clinical PI scores,according to the New York Heart Association(NYHA)functional classification criteria,patients were classified into grade Ⅱ(92 cases),grade Ⅲ(79 cases),and grade IV(53 cases).Based on the survival status of 28 days,patients were stratified into good(n=151)and poor(n=73)prognosis group.In addition,224 elderly patients with simple CHF were included as the control group during the same period of the study.A multifactorial Logistic regression model was used to analyze the factors influencing the prognosis of elderly CHF patients with PI;the predictive value of PCT,cTnⅠ,and ChE for the prognosis of elderly CHF patients with PI was assessed using receiver operator characteristic curves.Results Compared with the control group,the serum PCT and cTnⅠ levels in the study group increased,while ChE levels decreased(P<0.05).The serum PCT and cTnⅠ levels gradually increased and ChE levels gradually decreased in mild,moderate,severe,and grade Ⅱ,Ⅲ,andⅣpatients.Compared with the good prognosis group,the poor prognosis group had a higher proportion of patients with smoking history,diabetes,combined respiratory diseases,and cardiac function grades ofⅢand Ⅳ(P<0.05).The serum PCT and cTnⅠ levels increased,and the ChE level decreased(P<0.05).NYHA heart function Ⅲ-Ⅳ,combined with diabetes and respiratory diseases,and elevated serum levels of PCT and cTnⅠ were independently associated with poorer prognosis in this cohort of elderly patients with CHF and PI,while elevated serum ChE levels are protective factors for the prognosis of elderly patients with CHF and PI(P<0.05).According to the ROC curve,the AUC values of serum PCT,cTnⅠ,and ChE for predicting the prognosis of elderly CHF patients with PI are 0.759,0.787,and 0.775,respectively.The AUC value predicted by the combination of the three is 0.939,and the combined detection of the three is better than the detection of any indicator alone(P<0.05).Conclusion The levels of PCT and cTnⅠin the serum of elderly CHF patients with PI increase,while the level of ChE decreases.The combination of the three factors has a better predictive effect on the prognosis of elderly CHF patients with PI.关键词
老年/慢性心力衰竭/肺部感染/降钙素原/心肌肌钙蛋白Ⅰ/胆碱酯酶类Key words
elderly/chronic heart failure/pulmonary infection/procalcitonin/cardiac troponin Ⅰ/cholinesterases引用本文复制引用
谭化,李佳红,张秀敬,贾营,李娜..血清降钙素原、心肌肌钙蛋白Ⅰ和胆碱酯酶的表达与老年慢性心力衰竭合并肺部感染患者病情及预后的相关性分析[J].老年医学与保健,2026,32(1):32-37,6.基金项目
河北省医学科学研究课题计划项目(20242374) （20242374）
