临床与实验病理学杂志2026，Vol.42Issue(3)：297-303,7.DOI:10.13315/j.cnki.cjcep.2026.03.003
伴FGFR2基因易位的肝内胆管癌临床病理特征
Clinicopathological features of intrahepatic cholangiocarcinoma with FGFR2 gene translocation
摘要
Abstract
Objective To investigate the clinicopathological characteristics and molecular features of intrahe-patic cholangiocarcinoma(ICC)with fibroblast growth factor receptor 2(FGFR2)gene translocation.Methods The clinical manifestations,imaging findings,pathological features,and molecular characteristics of eight cases of ICC with FGFR2 translocation were retrospectively analyzed and compared with those of 32 cases of FGFR2 translocation-negative ICC.Results Tumor cells in ICC with FGFR2 translocation were cuboidal or polygonal and exhibited anasto-mosing tubular,trabecular,solid nested,or papillary growth patterns within a fibrosclerotic stroma.Compared with FGFR2 translocation-negative ICC,FGFR2 translocation-positive ICC showed a higher rate of hepatitis B virus infec-tion(P=0.042)and more frequently demonstrated small bile duct type or mixed histological subtypes(P=0.037).The mutation or expression rates of p53,HER2,c-Met,and BRAF V600E tended to be lower in FGFR2 translocation-positive ICC,although the differences were not statistically significant(P>0.05).The area under the receiver operat-ing characteristic curve(AUC)for predicting FGFR2 translocation by combining sex,hepatitis B virus infection sta-tus,TNM stage,histological subtype,and tumor nuclear grade was 0.912(P<0.001),which was higher than that of any single feature alone.Compared with FGFR2-translocated ICC harboring wild-type TP53,FGFR2-translocated ICC with TP53 co-mutation exhibited a higher nuclear grade(P=0.036),more advanced TNM stage(P=0.036),and poorer overall survival(P=0.009).Conclusion Distinct clinicopathological features are helpful for screening ICC with FGFR2 gene fusions and for identifying cases with TP53 co-mutation,thereby facilitating more precise treat-ment strategies for patients with ICC.关键词
肝内胆管癌/成纤维细胞生长因子受体2/基因易位/基因融合Key words
intrahepatic cholangiocarcinoma/fibroblast growth factor receptor 2/gene translocation/gene fusion分类
医药卫生引用本文复制引用
眭怡群,姚娟,叶振宇,徐蒙蒙,王志明,张永胜,曹志飞..伴FGFR2基因易位的肝内胆管癌临床病理特征[J].临床与实验病理学杂志,2026,42(3):297-303,7.基金项目
苏州市重点专科、学科建设托举工程项目(XKTJ-XK202410) Suzhou Key Specialties and Disciplines Construction Project for Supporting and Promoting Develop-ment(XKTJ-XK202410) （XKTJ-XK202410）
