临床肝胆病杂志2026，Vol.42Issue(2)：286-292,7.DOI:10.12449/JCH260206
慢加急性肝衰竭前期的研究现状
Current status of research on pre-acute-on-chronic liver failure
摘要
Abstract
Acute-on-chronic liver failure(ACLF)is a syndrome with high mortality triggered by acute predisposing factors in patients with underlying chronic liver diseases.Clinical studies have shown that ACLF can be reversed to a certain degree,and early intervention can improve patient prognosis,whereas delayed diagnosis and treatment can lead to a significant increase in mortality.In recent years,scholars in this field have proposed the concept of"pre-acute-on-chronic liver failure(Pre-ACLF)",which aims to improve clinical outcomes through early identification and intervention.This article systematically reviews the origin of the Pre-ACLF concept and its latest definitions in China and globally,summarizes the latest research advances in Pre-ACLF in terms of traditional clinical-laboratory parameters,high-throughput omics,and molecular biological mechanisms,and proposes the important clinical need for further unifying the definition of Pre-ACLF.关键词
慢加急性肝功能衰竭/终末期肝病/早期诊断Key words
Acute-On-Chronic Liver Failure/End Stage Liver Disease/Early Diagnosis引用本文复制引用
赵睿,焦婧然,陈煜..慢加急性肝衰竭前期的研究现状[J].临床肝胆病杂志,2026,42(2):286-292,7.基金项目
首都卫生发展科研专项项目(首发2024-1-2181) （首发2024-1-2181）
高层次公共卫生技术人才建设项目资助(学科带头人-01-12) （学科带头人-01-12）
北京市医院管理中心"登峰"计划专项经费资助(DFL20221501) （DFL20221501）
国家重点研发计划项目(2022YFC2304402) Capital's Funds for Health Improvement and Research(CFH2024-1-2181) （2022YFC2304402）
Construction Project of High-level Technology Talents in Public Health(Discipline leader-01-12) （Discipline leader-01-12）
Beijing Hospitals Authority's Ascent Plan(DFL20221501) （DFL20221501）
National Key Research and Development Program of China(2022YFC2304402) （2022YFC2304402）
