内科理论与实践2026，Vol.21Issue(1)：28-38,11.DOI:10.16138/j.1673-6087.2026.01.04
运动联合营养干预对老年肌少症体成分和躯体功能及睡眠质量的影响
Effects of exercise combined with nutrition intervention on body composition,physical function and sleep quality in elderly patients with sarcopenia
摘要
Abstract
Objective To investigate the effects of combined aerobic and resistance training along with nutritional supplementation on body composition,physical function,and sleep quality in elderly patients with sarcopenia.Methods A total of 83 elderly outpatients and inpatients with sarcopenia from the Department of Respiratory Rehabilitation at the Fourth Rehabilitation Hospital of Shanghai between January and June 2024 were enrolled,and were randomly assigned to a control group(aerobic training only,n=42)or an intervention group[combined aerobic and resistance training+whey protein supplementation containing vitamin D3 and beta-hydroxy-beta-methylbutyrate(HMB),n=41]for a 12-week intervention.Measurements including skeletal muscle index(SMI),25-hydroxyvitamin D level,grip strength,6-meter gait speed,and short physical performance battery(SPPB)score were examined before and after treatment.Sleep quality was assessed using the Pittsburgh sleep quality index(PSQI),insomnia severity index(ISI),and Epworth sleepiness scale(ESS).Results After treatment,the intervention group showed significantly greater improvements than the control group in SMI,25-hydroxyvitamin D level,6-meter gait speed,and total SPPB score(all P<0.05).The change in 5-time sit-to-stand performance was also significantly greater in the intervention group(P<0.05).Regarding sleep quality,both groups demonstrated significant post-intervention improvements in subjective sleep quality,sleep efficiency,total PSQI score,and ISI score(all P<0.05).Compared with the control group,the intervention group showed more pronounced improvements in subjective sleep quality,sleep duration,sleep disorders,total PSQI score,ISI score,and ESS score(all P<0.05).Logistic regression analysis indicated that the intervention modality[odds ratio(OR)=2.698,P=0.020]and comorbid osteoporosis(OR=2.362,P=0.043)were both associated with the improvement of sleep quality in patients.Conclusions Compared with aerobic training alone,a combined intervention of aerobic and resistance training with nutritional supplementation is more effective in improving muscle function and sleep quality in elderly patients with sarcopenia.The intervention modality and the presence of comorbid osteoporosis are significant factors influencing the efficacy of sleep quality improvement.关键词
肌少症/抗阻训练/有氧训练/维生素D3/β-羟基-β-甲基丁酸盐/乳清蛋白Key words
sarcopenia/resistance training/aerobic training/vitamin D3/beta-hydroxy-beta-methylbutyrate/whey-protein分类
医药卫生引用本文复制引用
张音,沈宏华,许轶明,杜井波,刘杰,吴顺军,凌小楠,任蕾..运动联合营养干预对老年肌少症体成分和躯体功能及睡眠质量的影响[J].内科理论与实践,2026,21(1):28-38,11.基金项目
静安区加强公共卫生体系建设三年行动计划(2023-2025年)(JAGW2023104-7) （2023-2025年）
