宁夏大学学报（自然科学版中英文）2026，Vol.47Issue(2)：158-167,184,11.DOI:10.20176/j.cnki.nxdz.20260204
迁移体的形成机制、生物学功能与研究展望
Formation Mechanism,Biological Function and Research Prospect of Migrasomes
摘要
Abstract
Migrasomes are membranous organelles discovered in recent years,produced by migrating cells.Their formation depends on cytoskeletal reorganization and changes in membrane tension triggered by integrins and extracellular matrix during cell migration,and they are mainly distributed at the ends or branching points of retraction fibers.The migrasome is a vesicular structure with a diameter of approximately 0.5-3.0 μm,contain-ing numerous small vesicles and a variety of biologically active molecules.Migrasomes play critical roles in diverse physiological and pathological contexts,including embryonic development,substance transport,mito-chondrial quality control,and coagulation regulation.In this review,we summarize the molecular mechanisms of migrasomes formation,their biological functions and roles in diseases,and discuss possible future research directions in this field.关键词
迁移体/收缩丝/细胞迁移/生物学功能Key words
migrasome/retraction fiber/cell migration/biological function分类
生物科学引用本文复制引用
胡海婧,刘佳升,钟健,张翠芳..迁移体的形成机制、生物学功能与研究展望[J].宁夏大学学报（自然科学版中英文）,2026,47(2):158-167,184,11.基金项目
国家自然科学基金面上项目(32470748) （32470748）
