内科理论与实践2026，Vol.21Issue(1)：62-67,6.DOI:10.16138/j.1673-6087.2026.01.09
共感染视角下人类免疫缺陷病毒与巨细胞病毒致神经系统损伤的机制及研究进展
Mechanisms and research progress of neurological damage caused by HIV and CMV from the perspective of co-infection
摘要
Abstract
With the widespread use of antiretroviral therapy(ART),the lifespan of individuals infected with human immunodeficiency virus(HIV)has been significantly prolonged;however,the prevalence of HIV-associated neurocognitive disorder(HAND)has not decreased correspondingly.Cytomegalovirus(CMV),as a latent opportunistic pathogen,is prevalent among HIV-infected individuals.Co-infection of CMV and HIV may exacerbate neurological damage through synergistic effects and has become a key factor affecting the long-term quality of life and prognosis of patients.This article aims to systematically elucidate the virological and immunological basis,molecular and cellular mechanisms,clinical phenotypes,diagnostic strategies,and therapeutic management of neurological damage caused by HIV and CMV co-infection,and to summarize the latest research progress and future directions,providing an integrated perspective for clinical practice and scientific research.关键词
人类免疫缺陷病毒/巨细胞病毒/共感染/神经系统/协同损伤Key words
human immunodeficiency virus/cytomegalovirus/co-infection/nervous system/synergistic damage分类
医药卫生引用本文复制引用
王耀,魏兰兰,初明,王福祥..共感染视角下人类免疫缺陷病毒与巨细胞病毒致神经系统损伤的机制及研究进展[J].内科理论与实践,2026,21(1):62-67,6.基金项目
国家自然科学基金面上项目(82272318) （82272318）
深圳市医学研究专项资金临床医学专项(C2401021) （C2401021）
深圳市第三人民医院 （）
经深圳市重大新发突发传染病临床医学研究中心项目(20230731105307002) （20230731105307002）
深圳市"三名工程"医学团队项目(SZSM202311033) （SZSM202311033）
