中南医学科学杂志2026，Vol.54Issue(2)：221-224,267,5.DOI:10.15972/j.cnki.43-1509/r.2026.02.007
少腹逐瘀丸对子宫内膜异位症大鼠MMP-9及TIMP-2表达的影响
Effects of Shaofu Zhuyu Pills on MMP-9 and TIMP-2 expression in rats with endometriosis
摘要
Abstract
Aim To analyze the effects of Shaofu Zhuyu Pills on the expression of matrix metalloproteinase-9(MMP-9)and tissue inhibitor of metalloproteinase-2(TIMP-2)in rats with endometriosis(EMs).Methods Female rats were randomly divided into a sham-operated group,a model group,a low-dose group(2.8 g/kg Shaofu Zhuyu Pills),a high-dose group(5.6 g/kg Shaofu Zhuyu Pills),and a gestrinone group(1.25 mg/kg gestrinone).EMs models were established in all groups except the sham-operated group.Serum levels of tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),IL-6,estradiol(E2),progesterone(P),follicle-stimulating hormone(FSH),and luteinizing hormone(LH)were compared.Pathological changes were observed by HE staining,and the mRNA and protein expression levels of MMP-9 and TIMP-2 in endometrial tissue were compared.Results Compared with the sham-operated group,the EMs model group showed significant pathological damage in the endometrial tissue.However,intervention with Shaofu Zhuyu Pills significantly improved this pathological damage(P<0.05).The mass and volume of ectopic lesions in the high-dose group and the gestrinone group were lower than those in the model group(P<0.05).Compared with the sham-operated group,the model,low-dose,high-dose,and gestrinone groups showed increased serum levels of TNF-α,IL-6,IL-1β,E2,P,and elevated mRNA and protein expression of MMP-9,while levels of FSH,LH,and mRNA and protein expression of TIMP-2 were decreased(P<0.05).Compared with the model group,these trends were reversed in the high-dose and gestrinone groups(P<0.05).Conclusion Shaofu Zhuyu Pill intervention in EMs rats can significantly improve pathological damage in en-dometrial tissue,alleviate inflammatory responses,and normalize sex hormone levels.Its mechanism of action may involve the down-regulation of MMP-9 expression and upregulation of TIMP-2 expression.关键词
少腹逐瘀丸/子宫内膜异位症/MMP-9/TIMP-2/大鼠Key words
Shaofu Zhuyu Pill/endometriosis/MMP-9/TIMP-2/rats分类
医药卫生引用本文复制引用
何雅惠,王思思,黄蓉,邓雅芹..少腹逐瘀丸对子宫内膜异位症大鼠MMP-9及TIMP-2表达的影响[J].中南医学科学杂志,2026,54(2):221-224,267,5.基金项目
湖南中医药大学校院联合基金(2024XYLH234) （2024XYLH234）
