内科理论与实践2026，Vol.21Issue(1)：85-90,6.DOI:10.16138/j.1673-6087.2026.01.13
痛风与尿酸代谢相关的肠道及肠道外菌群调控机制的研究进展
Research progress on the regulatory mechanisms of gut and extraintestinal microbiota in gout and uric acid metabolism
摘要
Abstract
Gout is an autoinflammatory metabolic disorder characterized by dysregulation of uric acid metabolism.Recent advances in metagenomics have propelled in-depth research on gout-associated microbiota,with particular attention to the gut,oral,urinary microbiota and their regulatory roles in uric acid metabolism.Dysbiosis of the gout-related gut microbiota is typified by a reduction in probiotics and an increase in opportunistic pathogens,which can regulate uric acid production and excretion by affecting urate-metabolizing enzymes,urate transporters,intestinal barrier function,and inflammatory signaling pathways.Meanwhile,preliminary studies on oral and urinary microbiota suggest that they may not only serve as biomarkers but also participate in the inflammatory response of gout through mechanisms such as"oral-gut translocation"and alterations in urinary microbiota.Microecological interventions—including prebiotics,probiotics,microbiota transplantation,and bioactive compounds derived from traditional Chinese medicine—hold potential clinical translational value in gout management by improving microbial homeostasis,promoting extra-renal urate excretion,and alleviating inflammation.Future research should further elucidate the causal relationship between microbiota and gout,and develop precise microecological intervention strategies to provide theoretical basis and practical guidance for personalized treatment and disease management.关键词
痛风/高尿酸血症/肠道菌群/口腔菌群/尿液菌群/尿酸代谢Key words
gout/hyperuricemia/gut microbiota/oral microbiota/urinary microbiota/uric acid metabolism分类
医药卫生引用本文复制引用
刘志成,陈银子,杨一帆,徐健,刘爽..痛风与尿酸代谢相关的肠道及肠道外菌群调控机制的研究进展[J].内科理论与实践,2026,21(1):85-90,6.基金项目
国家自然科学基金项目(32270947) （32270947）
云南省"万人计划"专项培养计划任务(YN-WR-MY-2018-040) （YN-WR-MY-2018-040）
云南省卫生健康委员会医学领军人才培养计划(L-2019004) （L-2019004）
云南省科技厅科技计划项目(202301AY070001-159) （202301AY070001-159）
云南省"万人计划"青年拔尖人才(YNWR-QNBJ-2018-152) （YNWR-QNBJ-2018-152）
昆明医科大学第一附属医院"535"高层次人才青年学术骨干(2022535Q01) （2022535Q01）
白求恩·普爱医学研究基金(PAYJ-043) （PAYJ-043）
云南省临床医学中心科研项目(YWLCYXZX2023300076、2024YNLCYXZX0019,2024YNLCYXZX0031、2024YNLCYXZX0042) （YWLCYXZX2023300076、2024YNLCYXZX0019,2024YNLCYXZX0031、2024YNLCYXZX0042）
昆明医科大学2025年研究生教育创新基金(2025S042) （2025S042）
