世界针灸杂志（英文版）2026，Vol.36Issue(1)：67-72,6.DOI:10.1016/j.wjam.2025.12.008
针刺干预慢性疼痛伴抑郁的分子机制研究进展
Advances in molecular mechanisms of acupuncture in chronic pain with depression
摘要
Abstract
Chronic pain is often accompanied by depressive emotions,and they are interacted with each other,which is one of the crucial factors to affect the clinical efficacy on pain.Acupuncture therapy has the advantages of multi-dimensional and multi-target regulation,and it is remarkably effective on chronic pain and pain-related depressive emotions.This paper reviews the mechanism researches of acupuncture in treatment of chronic pain with depression.Research indicates that the primary molecular mechanism by which acupuncture exerts analgesic and anti-depressive effects involves the regulation of central ner-vous system neurotransmitters,including 5-hydroxytryptamine,glutamic acid,gamma-aminobutyric acid,and dopamine.Additionally,acupuncture inhibits inflammatory responses within the central nervous sys-tem,modulates the expression of neurotrophic factors,enhances neuronal synaptic plasticity,and regu-lates the BDNF/TrkB/CREB and ERK signaling pathways.These findings underscore the multifaceted and multi-targeted regulatory advantages of acupuncture.关键词
Acupuncture/Chronic pain/Depression/Molecular biology/Multidimensional regulationKey words
Acupuncture/Chronic pain/Depression/Molecular biology/Multidimensional regulation引用本文复制引用
马翠,魏玉婷,刘安国,叶钰娟,卢宏玉,严兴科..针刺干预慢性疼痛伴抑郁的分子机制研究进展[J].世界针灸杂志（英文版）,2026,36(1):67-72,6.基金项目
Supported by General Project of Gansu Provincial Joint Research Fund:25JRRA1173 （）
2023 Gansu Provincial Key Talent Program:No.2023[20] （）
Key Project of Scientific Research and Innovation Fund of Gansu University of Chinese Medicine:2023KCZD-6 （）
2025 Gansu Provincial Higher Education Innovation Fund Project:2025A-104 （）
2025 Gansu Provincial Graduate"Innovation Star"Project:2025CXZX-936 （）
2025 Gansu University of Chinese Medicine Graduate"Innovation and En-trepreneurship Fund"Project:2025CXCY-001. （）
