上海中医药杂志2026，Vol.60Issue(4)：63-67,74,6.DOI:10.16305/j.1007-1334.2026.z20250430001
基于"脑髓-脑玄府"理论分期辨治伴皮质下梗死和白质脑病的常染色体显性遗传性脑动脉病
Staging and differential treatment of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy based on"brain marrow-brain Xuanfu"theory
摘要
Abstract
Using the"brain marrow-brain Xuanfu"theory,this study categorizes and treats cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy(CADASIL).The core pathogenesis of this disease is"brain marrow malnutrition and dysfunction of the brain Xuanfu",and its progression follows a dynamic evolutionary pattern of a prodromal phase,a progressive phase,and a terminal decline phase.The study establishes the following principles for staged treatment:in the early stage,the focus is on nourishing essence and replenishing marrow;in the progressive stage,while consolidating the foundation and nurturing the root,greater emphasis is placed on resolving phlegm,dispersing stasis,and opening orifices to unblock the brain-spinal fluid pathway;in the terminal decline stage,the approach involves supporting the righteous qi to detoxify,promoting circulation through tonification,and combining offensive and tonifying therapies.And a proven case is presented.关键词
伴皮质下梗死和白质脑病的常染色体显性遗传性脑动脉病/脑髓/脑玄府/痴呆/中医药疗法Key words
cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy/brain marrow/brain Xuanfu/dementia/traditional Chinese medicine therapy引用本文复制引用
任耕庆,田浩,王垚,李楠楠,王丽晔,张含,刘晓旭,陈志刚..基于"脑髓-脑玄府"理论分期辨治伴皮质下梗死和白质脑病的常染色体显性遗传性脑动脉病[J].上海中医药杂志,2026,60(4):63-67,74,6.基金项目
国家卫健委科技重大专项(2023ZD0505803) （2023ZD0505803）
国家卫健委中央高水平中医医院临床科研业务费资助项目(DFRCZY-2024GJRC006) （DFRCZY-2024GJRC006）
国家中医药管理局十一五重点专科专项专病基金项目(040104001003) （040104001003）
