实用肿瘤杂志2026，Vol.41Issue(2)：147-153,7.DOI:10.13267/j.cnki.syzlzz.2026.020
PYCR1在结直肠癌诊断和随访中的价值分析
Value of PYCR1 in diagnosis and follow-up of colorectal cancer
摘要
Abstract
Objective To investigate the expression of pyrroline-5-carboxylate reductase 1(PYCR1)in the serum of patients with col-orectal cancer and its clinical value.Methods The expression of PYCR1 in colorectal adenocarcinoma tissues was analyzed in the Gene Expression Profiling Interactive Analysis(GEPIA)database.The serum samples and related data of 133 patients who were admitted to the Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine from February 2022 to December 2023 were collected,including 20 healthy subjects,31 patients with colorectal adenoma,28 pre-operative patients with colorectal adenocarcinoma,30 post-op-erative colorectal adenocarcinoma patients without recurrence,and 24 post-operative colorectal adenocarcinoma patients with recurrence.The expression of PYCR1 in the serum samples was detected by enzyme-linked immunosorbent assay.The correlations between the serum PYCR1 level and the clinical features and tumor markers of the patients were analyzed.The clinical value of serum PYCR1 level in the di-agnosis and follow-up of colorectal cancer was evaluated by receiver operating charateristic curves.Results The GEPIA database analysis showed that PYCR1 was highly expressed in colon adenocarcinoma and rectal adenocarcinoma tissues(both P<0.05).Serum PYCR1 levels were increased in patients with colorectal adenoma,pre-operative colorectal adenocarcinoma,and post-operative recurrence of colorectal adenocarcinoma(all P<0.05).The high level of serum PYCR1 was correlated with tumor size and distant metastasis(both P<0.05),strongly positively correlated with the levels of carcinoembryonic antigen(CEA)(r=0.832,P<0.01),and moderately positively correlated with carbo-hydrate antigen 19-9(CA19-9)(r=0.632,P<0.01),CA50(r=0.587,P<0.01),and CA242(r=0.574,P<0.01).Compared with the combined detection of CEA and CA19-9,the combined detection of serum PYCR1 and CEA had better sensitivity and negative predictive value in the diagnosis of colorectal cancer and prediction of post-operative recurrence.Conclusions The high level of serum PYCR1 is related to the progression of colorectal neoplasms,and the combined detection of serum PYCR1 and CEA has certain clinical value in the diagnosis and follow-up of colorectal cancer.关键词
结直肠癌/吡咯啉-5羧酸还原酶1/诊断/随访/肿瘤标志物Key words
colorectal cancer/pyrroline-5-carboxylate reductase 1/diagnosis/follow-up/tumor marker引用本文复制引用
马忠娜,周波蓉,宋雅楠,张苗,夏伟..PYCR1在结直肠癌诊断和随访中的价值分析[J].实用肿瘤杂志,2026,41(2):147-153,7.基金项目
国家自然科学基金(82204845) （82204845）
上海市科学技术委员会科技创新行动计划(22ZR1447900) （22ZR1447900）
上海市浦东新区卫生健康委员会学科建设项目(PWZxk2022-04) （PWZxk2022-04）
