天津中医药2026，Vol.43Issue(4)：456-460,5.DOI:10.11656/j.issn.1672-1519.2026.04.07
基于心肾代谢综合征探讨无症状期下肢动脉粥样硬化早期肾损伤与中医证素的相关性
A study on the correlation between early renal injury and traditional Chinese medicine syndrome elements in asymptomatic lower extremity atherosclerosis based on cardiovascular-kidney-metabolic syndrome
摘要
Abstract
[Objective]Based on the cardiovascular-kidney-metabolic(CKM)framework,this study aimed to explore the correlation between early renal injury and traditional Chinese medicine(TCM)syndrome elements in patients with asymptomatic lower extremity arterial atherosclerosis(LEAD).[Methods]A retrospective analysis was conducted on 216 asymptomatic LEAD patients,who were categorized into a normal microalbuminuria(MAU)group(MAU<30 mg/L,140 cases)and an abnormal MAU group(MAU≥30 mg/L,76 cases).The distribution of TCM syndrome elements was compared between groups.Spearman correlation and binary logistic regression were used to examine associations between syndrome elements and renal function indicators.[Results]The abnormal MAU group had significantly higher age,proportion of hypertension history,Crouse score,serum creatinine,and cystatin C,but lower ankle-brachial index(ABI)and estimated glomerular filtration rate(eGFR),P<0.05.The predominant TCM syndrome elements were phlegm-turbidity(50.0%),qi deficiency(47.7%),and blood stasis(43.5%).The proportion of phlegm-turbidity was significantly higher in the abnormal MAU group(61.8%)than in the normal group(43.6%,P<0.05).Logistic regression identified history of hypertension(OR=2.106),ABI(OR=0.153),and phlegm-turbidity(OR=2.043)as independent influencing factors for abnormal MAU(P<0.05).[Conclusion]Early renal injury in asymptomatic LEAD patients results from the synergistic effects of hypertension,vascular lesions,and metabolic disorders.The high prevalence of phlegm-turbidity syndrome element and its significant association with MAU abnormality suggest its core role in the"metabolic-vascular-renal"injury axis,providing a new perspective for integrated Chinese and Western medicine interventions.关键词
无症状期下肢动脉粥样硬化/早期肾损伤/心肾代谢综合征/中医证素Key words
asymptomatic lower extremity atherosclerosis/early renal injury/cardiovascular-kidney-metabolic syndrome/TCM syndrome elements分类
医药卫生引用本文复制引用
蒲昱伶,陈咸川,钱风华,姜恺,王兆政,张嘉伟,沈融..基于心肾代谢综合征探讨无症状期下肢动脉粥样硬化早期肾损伤与中医证素的相关性[J].天津中医药,2026,43(4):456-460,5.基金项目
上海市进一步加快中医药事业发展三年行动计划项目:中医优势病种培育建设项目[ZY(2018-2020)-ZYBZ-13]. （2018-2020）
