天津中医药大学学报2026，Vol.45Issue(3)：293-300,8.DOI:10.11656/j.issn.1673-9043.2026.03.06
核桃仁对补骨脂在大鼠体内的药代动力学影响
Effects of walnut kernel on the pharmacokinetics of psoralea corylifolia in rats
摘要
Abstract
[Objective]This experiment aimed to investigate the effect of walnut kernel on the pharmacokinetics of Psoralea corylifolia extract in rats.[Methods]Twelve male SD rats were divided into two groups(n=6 per group):the Psoralea corylifolia group(receiving Psoralea corylifolia extract at 1.05 g/kg)and the co-administration group(receiving Psoralea corylifolia extract at 1.05 g/kg plus walnut kernel at 0.66 g/kg).Approximately 300 μL of blood was collected from the orbital venous plexus before administration(0 h)and at 12 time points post-administration.The upper plasma layer was collected and analyzed using the established method.[Results]The pharmacokinetic parameters showed that the most of the compatible rats had decreased AUC and Cmax levels,including isopsoralen,bavachinin,isobavachalcone,neobavaisoflavone and bakuchalcone.[Conclusion]This study indicates that walnut kernel can reduce the systemic exposure levels and shorten the retention time of most active components of Psoralea corylifolia in rats,thereby altering its pharmacokinetic profile.This finding provides a pharmacokinetic perspective on the potential mechanism by which walnut kernel alleviates Psoralea corylifolia-induced hepatotoxicity.关键词
补骨脂/核桃仁/药代动力学/超高效液相色谱-串联质谱联用技术Key words
psoralea corylifolia/walnut kernel/pharmacokinetics/UHPLC-MS/MS分类
医药卫生引用本文复制引用
王爱习,曹靖浩,高俐,王金煜,张玥,周昆..核桃仁对补骨脂在大鼠体内的药代动力学影响[J].天津中医药大学学报,2026,45(3):293-300,8.基金项目
国家重点研发计划项目(2022YFC3502103-01) （2022YFC3502103-01）
组分中药国家重点实验室课题项目(CBCM2023203) （CBCM2023203）
天津中医药大学研究生科研创新项目(YJSKC-20240029). （YJSKC-20240029）
