现代医药卫生2026，Vol.42Issue(3)：503-507,5.DOI:10.3969/j.issn.1009-5519.2026.03.005
肺癌ALK(Ventana/D5F3)非特异性表达5例及其临床特征分析
Analysis of 5 cases of nonspecific expression of ALK(Ventana/D5F3)in non-adenocarcinoma lung cancer and their clinical features
黄运 1陆典科 2钟丽君 1陈晓童 1吴迎辉1
作者信息
- 1. 玉林市第一人民医院病理科,广西 玉林 537000
- 2. 玉林市红十字会医院全科医学科,广西 玉林 537000
- 折叠
摘要
Abstract
Objective To investigate the expression of anaplastic lymphoma kinase(ALK,Ventana/D5F3)in five cases of non-adenocarcinoma lung cancer and analyze their related clinicopathological features.Methods A total of five specimens from patients with non-adenocarcinoma lung cancer who were examined and diagnosed in the Department of Pathology of The First People's Hospital of Yulin form December 2023 to December 2024 were collected.Among them,there were three cases of small cell carcinoma,one case of squa-mous cell carcinoma,and one case of small cell carcinoma transformation after squamous cell carcinoma treat-ment.Immunohistochemistry was performed to detect ALK protein,and fluorescence in situ hybridization(FISH)was used for verification.Results Among the five lung cancer patients,four were male and one was female,aged from 52 to 82 years with a median age of 67 years.Squamous cell carcinoma tumor cells were round or oval,with an increased nuclear-cytoplasmic ratio,abundant and lightly stained cytoplasm,and visible mitotic figures.Microscopic observation of small cell carcinoma showed that the tumor cells were irregular,with salt-and-pepper nuclei,scarce cytoplasm,some nuclei were deformed by compression,and mitotic figures were easily seen.The results of ALK(Ventana/D5F3)immunohistochemistry showed strong positive expres-sion in the cytoplasm(the positive proportion ranging from 5％to 40％),while no ALK fusion gene was de-tected by FISH.Conclusion ALK(Ventana/D5F3)is predominantly expressed in pulmonary non-small cell lung cancer,mainly adenocarcinoma,but may have nonspecific expression in other types of tumors.关键词
肺肿瘤/间变性淋巴瘤激酶/免疫组织化学/荧光原位杂交Key words
Lung neoplasms/Anaplastic lymphoma kinase/Immunohistochemistry/Fluores-cence in situ hybridization分类
医药卫生引用本文复制引用
黄运,陆典科,钟丽君,陈晓童,吴迎辉..肺癌ALK(Ventana/D5F3)非特异性表达5例及其临床特征分析[J].现代医药卫生,2026,42(3):503-507,5.
