Abstract
Objective To explore the application of pepsinogen Ⅰ(PGⅠ)and PGⅡ combined with neuron-specific enolase(NSE)and cancer antigen 15-3(CA15-3)in the early diagnosis of gastric cancer.Methods A total of 81 patients with gastric cancer and 81 patients with benign gastric lesions in the hospital were enrolled as malignant group and benign group from January 2023 to October 2024,respectively.The se-rological indexes in the two groups were compared,and the diagnostic value of the serological indexes for early gastric cancer was analyzed by receiver operating characteristic(ROC)curves.The serological levels of pa-tients with different pathological characteristics in the malignant group were analyzed,and the correlation be-tween serological indexes and early clinicopathological characteristics of gastric cancer was analyzed by Spearman's rank correlation coefficient.Results The serum PGⅠ level in malignant group was lower than that in benign group,while levels of PGⅡ,NSE and CA15-3 were higher than those in benign group(P<0.05).ROC curve analysis showed that the area under the curve(AUC),sensitivity and specificity of serum PGⅠ,PGⅡ,NSE,CA15-3 alone and their combined detection in the early diagnosis of gastric cancer were 0.716,0.762,0.635,0.641,0.810;76.54％,80.25％,67.90％,69.14％,95.06％;and 77.50％,80.00％,70.00％,68.75％,66.25％,respectively(P<0.05).Taking pathological examination as the gold standard,the cut-off value obtained by ROC analysis was used as the diagnostic criterion.The results showed that Kappa values of PGⅠ,PGⅡ,NSE,CA15-3 and combined detection were 0.605,0.654,0.506,0.543 and 0.716,re-spectively(P<0.05).In the malignant group,there was no significant difference in levels of serum PGⅠ,PGⅡ,NSE and CA15-3 among patients with different pathological types(P>0.05).In the malignant group,PGⅠ level in patients with tumor diameter>3 cm and lymph node metastasis was lower than those with tumor diameter≤3 cm and lymph node non-metastasis,while the levels of serum PGⅡ,NSE,and CA15-3 were higher than those with tumor diameter≤3 cm and lymph node non-metastasis(P<0.05).Spearman rank correlation analysis showed that serum PGⅠ was negatively correlated with tumor diameter>3 cm and lymph node metastasis,while PGⅡ,NSE and CA15-3 were positively correlated with them(P<0.05).Con-clusion The combined detection of PGⅠ,PGⅡ,NSE and CA15-3 has high diagnostic efficiency in the early diagnosis of gastric cancer,providing a reliable serological basis for the early screening of gastric cancer.关键词
胃肿瘤/胃蛋白酶原类/癌抗原15-3/早期诊断Key words
Gastric cancer/Pepsinogens/Cancer antigen 15-3/Early diagnosis分类
医药卫生
