现代医药卫生2026，Vol.42Issue(3)：517-521,526,6.DOI:10.3969/j.issn.1009-5519.2026.03.008
肿瘤坏死因子在肿瘤发生发展中的作用及其机制研究进展
Research advances in the role of TNF in tumorigenesis and progression and its underlying mechanisms
丁一凡 1何非凡 1储熙 1蔡宏宙1
作者信息
- 1. 江苏省肿瘤医院/南京医科大学附属肿瘤医院/江苏省肿瘤防治研究所,江苏 南京 210009
- 折叠
摘要
Abstract
Tumor necrosis factor(TNF)plays a central dual role in oncology:it not only drives potent antitumor immunity but also serves as a key factor promoting malignant tumor progression and metastasis.This functional differentiation is rooted in the dynamic regulation of the tumor necrosis factor receptor 1/2(TNFR1/2)signaling pathways.The elaborate assembly of intracellular signalosomes and critical post-trans-lational modifications such as the palmitoylation of Receptor-Interacting Serine/Threonine-Protein Kinase 1(RIPK1)and others collectively determine the cellular fate choice between apoptosis and survival.Within the tumor microenvironment,TNF reshapes the immune landscape in a highly context-dependent manner,by ei-ther enhancing the metabolic fitness of natural killer cells or inducing immunosuppressive regulatory T cell subsets.To address the toxicity dilemma of systemic TNF administration,the current research paradigm has shifted towards spatiotemporal control.Strategies exemplified by the oncolytic virus TILT-123,which enables precise localized intratumoral production of TNF-α and Interleukin-2,have demonstrated potent antitumor ef-ficacy and the potential to induce systemic antitumor immune memory in clinical trials.Future research will focus on developing multispecific molecules,intelligent drug delivery systems,and systematically deciphering the functional network of the entire TNF superfamily,aiming to usher in a new era of more precise tumor im-munological intervention.关键词
肿瘤坏死因子/肿瘤微环境/免疫治疗/溶瘤病毒/生物标志物/综述Key words
Tumor necrosis factor/Tumor microenvironment/Immunotherapy/Oncolytic virus/Biomarkers/Review分类
医药卫生引用本文复制引用
丁一凡,何非凡,储熙,蔡宏宙..肿瘤坏死因子在肿瘤发生发展中的作用及其机制研究进展[J].现代医药卫生,2026,42(3):517-521,526,6.
