协和医学杂志2026，Vol.17Issue(2)：324-333,10.DOI:10.12290/xhyxzz.2026-0103
巨噬细胞表型重编程与肾脏纤维化:从机制解析到靶向策略
Macrophage Phenotypic Reprogramming and Renal Fibrosis:From Mechanistic Insights to Targeted Therapy
摘要
Abstract
Renal fibrosis represents the core pathway through which chronic kidney disease progresses to end-stage renal failure.Therapeutic strategies targeting renal fibrosis provide an important approach for clinically mitigating the transition from acute kidney injury to chronic kidney disease.Macrophages,owing to their high heterogeneity in origin and phenotype,play a significant role in various stages of acute inflammation,tissue re-pair,and fibrosis,thereby holding substantial promise for the treatment of renal fibrosis.This review summarizes the pivotal role of renal macrophages in the transition from acute kidney injury to chronic kidney disease,with a focus on their temporal phenotypic reprogramming characteristics and the fibrotic microenvironment interaction network constituted by injured tubules,macrophages,and fibroblasts.On this basis,we systemati-cally outline four core categories of macrophage-targeted intervention strategies:modulation of upstream signaling pathways,induction of macrophage phenotypic reprogramming,blockade of profibrotic factors and their downstream pathways,and selective depletion or engineered modification of profibrotic macrophage subsets.This review aims to provide new insights for future exploration of the timing,precision,and efficacy of macrophage-targeted therapies.关键词
巨噬细胞/急性肾损伤/慢性肾脏病/肾脏纤维化Key words
macrophage/acute kidney injury/chronic kidney disease/renal fibrosis分类
医药卫生引用本文复制引用
祝家豪,徐鲁斌,陈丽萌..巨噬细胞表型重编程与肾脏纤维化:从机制解析到靶向策略[J].协和医学杂志,2026,17(2):324-333,10.基金项目
中央高水平医院临床科研专项(2025-PUMCH-C-023) （2025-PUMCH-C-023）
北京市自然科学基金(7252112) （7252112）
北京高层次创新创业人才支持计划"医疗卫生平台"领军人才项目(G202511003) （G202511003）
中国医学科学院医学与健康科技创新工程(CIFMS 2024-I2M-C&T-C-003) （CIFMS 2024-I2M-C&T-C-003）
国家自然科学基金(82570826) National High Level Hospital Clinical Research Funding(2025-PUMCH-C-023) （82570826）
Beijing Natural Science Founda-tion(7252112) （7252112）
Beijing High Level Innovation and Entrepreneurship Talent Support Program-Healthcare Platform leading talent projects(G202511003) （G202511003）
CAMS Innovation Fund for Medical Sciences(CIFMS 2024-I2M-C&T-C-003) （CIFMS 2024-I2M-C&T-C-003）
National Natural Science Foundation of China(82570826) （82570826）
