畜牧兽医学报2026，Vol.57Issue(3)：1177-1186,10.DOI:10.11843/j.issn.0366-6964.2026.03.001
IGF-1在哺乳动物卵泡发育中的作用
The Role of IGF-1 in Mammalian Follicular Development
摘要
Abstract
During the estrous cycle of mammals,a large number of follicles are recruited.Typically,only one follicle is selected for dominance and ovulation in monotocous(single-offspring)species per cycle,while only a few follicles are selected for dominance in polytocous(multiple-offspring)species.The vast majority of the remaining follicles undergo atresia.In recent years,significant progress has been made in research focusing on follicular dominance selection,although the underlying mechanisms have not yet been fully elucidated.Insulin-like growth factor 1(IGF-1)has been demonstrated to play a crucial role in follicular development.This review summarizes the roles and mechanisms of IGF-1 in mammalian follicular development,focusing on its involvement in dominant follicle selection,promotion of follicular growth and development,inhibition of granulosa cell apoptosis,and maintenance of normal reproductive performance in female mammals.关键词
IGF-1/哺乳动物/卵泡发育/激素调控/内分泌Key words
IGF-1/mammal/follicular development/hormonal regulation/endocrine分类
农业科技引用本文复制引用
刘宣均,李一兆,刘开元,陈姗姗,冯浩义,李新建,曾申明,杨峰..IGF-1在哺乳动物卵泡发育中的作用[J].畜牧兽医学报,2026,57(3):1177-1186,10.基金项目
国家自然科学基金(32202671 （）
82400109) （）
中国博士后科学基金(2023M730999) （2023M730999）
2024年河南省科技研究项目 （）
