纤维素科学与技术2026，Vol.34Issue(1)：59-67,9.DOI:10.16561/j.cnki.xws.2026.01.08
介孔碳负载改性叶绿素Ce6光动力治疗肿瘤机制的研究
Investigation of the Mechanism of Tumor Photodynamic Therapy Mediated by Ce6-Loaded Mesoporous Carbon Nanoplatforms
摘要
Abstract
Spherical mesoporous Fe-N-DNC was synthesized using dopamine hydrochloride as the carbon precursor via a soft-templated strategy,with Fe3O4 nanoparticles confined in the mesoporous carbon framework.Chlorin e6(Ce6)was subsequently loaded onto the Fe-N-DNC surface through π–π interactions,followed by polyethylene glycol(PEG)modification to obtain PEG@Ce6@Fe-N-DNC nanomaterials.The morphology,structural features,and chemical composition of the as-prepared nanomaterials were systematically characterized by scanning electron microscopy(SEM),transmission electron microscopy(TEM),X-ray diffraction(XRD),X-ray photoelectron spectroscopy(XPS),Fourier transform infrared spectroscopy(FTIR),and Raman spectroscopy,together with an evaluation of singlet oxygen generation capability.The results demonstrate that PEG@Ce6@Fe-N-DNC exhibits a uniform spherical morphology with an average particle size of approximately 200 nm and favorable photodynamic activity.The photodynamic therapeutic performance of PEG@Ce6@Fe-N-DNC was further evaluated in A431 cutaneous squamous cell carcinoma cells under 660 nm light irradiation.The results show that PEG@Ce6@Fe-N-DNC induces significant cytotoxicity upon light activation,with an IC₅₀ value of 10 μg/mL.These findings indicate that PEG@Ce6@Fe-N-DNC nanomaterials exhibit effective single-modal photodynamic antitumor activity and provide experimental evidence for the application of Ce6-based nanomaterials in the photodynamic treatment of cutaneous squamous cell carcinoma.关键词
介孔碳纳米材料/改性叶绿素/光动力疗法/单线态氧/A431皮肤癌Key words
mesoporous carbon nanomaterial/chlorin e6(Ce6)/photodynamic therapy(PDT)/singlet oxygen/A431 skin cancer分类
医药卫生引用本文复制引用
李国定,黄浩,彭翔,吴泳瑶,周霖,张涵苡,靳焘..介孔碳负载改性叶绿素Ce6光动力治疗肿瘤机制的研究[J].纤维素科学与技术,2026,34(1):59-67,9.基金项目
重庆市自然科学基金(CSTB2022NSCQ-MSX0986) （CSTB2022NSCQ-MSX0986）
