畜牧兽医学报2026，Vol.57Issue(3)：1195-1204,10.DOI:10.11843/j.issn.0366-6964.2026.03.003
动物乳腺生物反应器的应用进展及研究前景
Application Progress and Research Prospects of Animal Mammary Gland Bioreactor
摘要
Abstract
Animal mammary bioreactors utilize mammalian-specific lactoprotein gene promoters to direct the efficient and specific expression of exogenous genes in the animal mammary gland,ultimately obtaining protein expression products through the secretory function of the mammalian mammary gland.This article focuses on the application progress and research prospects of animal mammary bioreactors,providing theoretical reference value for future research and industrial development of animal mammary bioreactors.Through literature review and practical research,a brief overview is provided from the aspects of the principle,characteristics,target animal selection,application fields,challenges faced,and development prospects of animal mammary bioreactors.Different animal mammary bioreactors have their own advantages and disadvantages,and target animals can be reasonably selected according to actual needs and production practices.Compared with other traditional expression systems,mammary bioreactors are a novel expression mode with advantages such as high yield,easy purification,low cost,high biological activity,and high safety,and are widely used in improving animal milk quality,producing recombinant pharmaceutical proteins,making antibodies,synthesizing genetic engineering vaccines,and other fields.Although many influencing factors of mammary bioreactors are still unknown,there are some problems that urgently need to be solved,and challenges are also faced.However,with the rise of gene editing technologies such as CRISPR/Cas9,as long as technological innovation and research and development investment are continuously increased,their application prospects are very broad.关键词
乳腺生物反应器/蛋白表达产物/重组医药蛋白/基因编辑Key words
mammary gland bioreactor/protein expression product/recombinant pharmaceutical protein/gene editing分类
农业科技引用本文复制引用
宋绍征,周哲,顾悦,钟小惠,吉柳,顾乐盈,鲍红光..动物乳腺生物反应器的应用进展及研究前景[J].畜牧兽医学报,2026,57(3):1195-1204,10.基金项目
江苏省高校"青蓝工程"优秀青年骨干教师项目(苏教师函[2021]11号) （苏教师函[2021]11号）
江苏省高校自然科学基金(20KJB360007) （20KJB360007）
