畜牧兽医学报2026，Vol.57Issue(3)：1205-1213,9.DOI:10.11843/j.issn.0366-6964.2026.03.004
四倍体补偿技术在家畜胚胎中的研究现状与应用前景
Current Status and Application Prospects of Tetraploidy Compensation Technology in Domestic Animal Embryos
摘要
Abstract
Tetraploid embryo technology is an important tool for livestock genetic breeding and biomedical research,and its application potential is becoming more and more prominent.In this paper,we systematically review the key technologies,bottlenecks and future development directions of tetraploid in vitro embryo production in livestock.It focuses on the induction methods(e.g.,physical,chemical,and biological methods),optimization of in vitro culture systems,and factors affecting the developmental efficiency of tetraploid embryos of major livestock species,such as pigs,cows,and sheep.By comparing the developmental characteristics of tetraploid embryos from different species,we reveal the core limiting factors such as abnormal activation of the embryonic genome and defective placental development.Combined with the cutting-edge technologies of gene editing and embryo-like culture,the application of this echnology in the fields of efficient breeding,disease modeling and xenotransplantation is envisioned,with a view to providing theoretical references and technological guidance for related research.关键词
家畜/四倍体胚胎/体外生产/胚胎技术/胚胎发育Key words
livestock/tetraploid embryos/in vitro production/embryo technology/embryo development分类
农业科技引用本文复制引用
马莉,闵思蕊,刘新峰,陈强..四倍体补偿技术在家畜胚胎中的研究现状与应用前景[J].畜牧兽医学报,2026,57(3):1205-1213,9.基金项目
宁夏回族自治区重点研发计划项目(引才专项)(2024BEH04111) （引才专项）
国家自然科学基金(32160791) （32160791）
宁夏自然科学基金重点项目(2024AAC02019) （2024AAC02019）
