云南民族大学学报（自然科学版）2026，Vol.35Issue(2)：216-223,8.DOI:10.3969/j.issn.1672-8513.2026.02.008
莪术醇调控谷氨酰胺代谢分子机制的生物信息学研究
Bioinformatics study on the molecular mechanisms of curcumol in regulating glutamine metabolism
摘要
Abstract
The potential targets of curcumol were retrieved from the PharmMapper and Swiss Target Prediction databases,while glutamine metabolism-related targets were mined from GeneCards,Online Mendelian Inheritance in Man(OMIM),and the Comparative Toxicogenomics Database(CTD).After screening,the intersection targets were subjected to protein-protein interaction(PPI)network analysis.Gene Ontology(GO)annotation and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analysis were performed using the Metascape platform.Molecular docking was conducted with AutoDock software to validate the binding activity between key active components and disease targets.The study identified 150 interactive targets of curcumol involved in glutamine metabolism regulation,with genes such as MAPK1,HSP90AA1,and PRKACA ranking high in connectivity.Molecular docking results indicated that curcumol exhibited high affinity for HSP90AA1,EGFR,ALB,IGF1,MAPK1,and MMP9,suggesting its potential inhibitory activity on glutamine metabolism.In conclusion,network pharmacology and molecular docking predicted that curcumol could regulate glutamine metabolism through multiple targets and pathways,providing a theoretical basis for further experimental research.关键词
莪术醇/谷氨酰胺代谢/网络药理学/分子对接Key words
curcumol/glutamine metabolism/network pharmacology/molecular docking分类
医药卫生引用本文复制引用
黄艳青,梁诗雨,郑惠文,鲜芯蕊,苏毅强,郑洋,王佳慧..莪术醇调控谷氨酰胺代谢分子机制的生物信息学研究[J].云南民族大学学报（自然科学版）,2026,35(2):216-223,8.基金项目
国家自然科学基金(82204755、81960751、81660705) （82204755、81960751、81660705）
广西自然科学基金青年基金(2023GXNSFBA297094) （2023GXNSFBA297094）
广西中青年教师科研基础能力提升项目(2022KY1667) （2022KY1667）
广西中医药大学一流学科项目(2019XK141) （2019XK141）
广西中医药大学青年基金(2020QN006、2022QN008) （2020QN006、2022QN008）
广西中医药大学赛恩斯新医药学院科研项目(2022MS002、2022MS008、2022QJ001) （2022MS002、2022MS008、2022QJ001）
广西中医药大学赛恩斯新医药学院省级大学生创新创业项目(S202213643005). （S202213643005）
