医学新知2026，Vol.36Issue(3)：335-341,7.DOI:10.12173/j.issn.1004-5511.202506056
前列腺癌的生物力学视角:病理机制、诊断革新与靶向干预
Biomechanical perspective of prostate cancer:pathological mechanism,diagnostic innovation and targeted intervention
摘要
Abstract
Prostate cancer(PCa)is one of the most prevalent malignancies in men worldwide.Its progression is not only driven by molecular and genetic alterations but also significantly influenced by mechanical cues in the tumor microenvironment.Biomechanics,an interdisciplinary field exploring the role of physical forces in biological systems,has emerged as a novel lens for cancer research.This review summarizes recent advances in the biomechanical study of PCa,including tissue stiffness heterogeneity,cellular mechanical phenotypes,extracellular matrix remodeling,and fluid shear stress in tumor progression.We further highlight the clinical implications of biomechanics in early detection,benign-malignant lesion discrimination,and multi-modal diagnostic imaging.Moreover,the therapeutic potential of biomechanical approaches was discussed,including modulation of therapeutic sensitivity,targeting mechano-signaling pathways,developing mechanically responsive nanocarriers,and applying external mechanical interventions.Despite current challenges such as a lack of standardization and limited clinical translation,interdisciplinary collaboration holds promise for advancing biomechanically informed precision medicine in PCa.关键词
前列腺癌/生物力学/肿瘤微环境/组织刚度/细胞外基质重构/弹性成像/血流剪切力Key words
Prostate cancer/Biomechanics/Tumor microenvironment/Tissue stiffness/Extracellular matrix remodeling/Elastography/Fluid shear stress分类
医药卫生引用本文复制引用
高锦,郭静,米子硕,陈昊..前列腺癌的生物力学视角:病理机制、诊断革新与靶向干预[J].医学新知,2026,36(3):335-341,7.基金项目
国家自然科学基金青年科学基金项目(82405589) （82405589）
江苏省自然科学基金青年基金项目(BK20040741) （BK20040741）
江苏省中医药科技发展计划青年人才项目(QN202308) （QN202308）
