医学新知2026，Vol.36Issue(3)：342-347,6.DOI:10.12173/j.issn.1004-5511.202408034
牙龈卟啉单胞菌在消化系统肿瘤发生发展中的角色和相关机制
Role and related mechanisms of Porphyromonas gingivalis in the occurrence and development of digestive system tumors
摘要
Abstract
The pathogenic role of Porphyromonas gingivalis(P.gingivalis),a key pathogen in periodontitis,has been well documented to extend far beyond the oral cavity.P.gingivalis can be specifically detected in digestive system tumor tissues,and its infection abundance is closely associated with tumor invasion,metastasis,and poor prognosis in patients.This study systematically reviews basic and clinical research on the association between P.gingivalis and digestive system tumors including oral cancer,esophageal cancer,pancreatic cancer,liver cancer,and colorectal cancer.The potential molecular mechanisms underlying P.gingivalis-induced tumor initiation and progression were further elucidated thoroughly,aiming to provide new theoretical basis and research directions for risk warning,early diagnosis,and targeted therapy of digestive system tumors.关键词
牙龈卟啉单胞菌/消化系统/肿瘤发生发展/分子机制Key words
Porphyromonas gingivalis/Digestive system/Tumor pathogenesis and progression/Molecular mechanism分类
医药卫生引用本文复制引用
李婧雅,孙佳春,孔金玉,高社干..牙龈卟啉单胞菌在消化系统肿瘤发生发展中的角色和相关机制[J].医学新知,2026,36(3):342-347,6.基金项目
国家自然科学基金面上项目(81972571 （）
81872500) （）
