空军军医大学学报2026，Vol.47Issue(3)：416-420,5.DOI:10.13276/j.issn.2097-1656.2026.03.016
基于808 nm波长的光生物治疗对深Ⅱ度烧伤大鼠瘙痒行为的研究
Role of 808-nm photobiomodulation in modulating itch behavior following deep partial-thickness burn injury in rats
摘要
Abstract
Objective To observe the effect of 808 nm photobiomodulation(PBM)on early-stage itch behavior and evaluate its role in burn wound healing and the prevention of itch occurrence.Methods A deep partial-thickness(second-degree)burn model was established on the backs of rats using a heated copper block method.Intervention with 808 nm near-infrared light was administered after injury.Itch behavior was assessed via a scratching test;pathological differences were observed through HE and Masson staining;and transcriptome sequencing was used to compare the transcriptional profiles of wounds across different groups.Results Compared with the burn control group,the PBM group showed an increased wound healing rate and enhanced collagen deposition.No significant increasing trend was observed in itch-related scratching behavior.Transcriptome analysis revealed that PBM primarily affected immune-and metabolism-related pathways,with no significant enhancement of neurostimulation-associated signaling.Conclusion PBM with 808 nm promotes burn wound repair without increasing the burden of itching.This suggests it has good safety and potential for application during the early intervention stage for combat and burn injuries,providing an experimental basis for the deployment of non-pharmacological rapid intervention methods in military medical support.关键词
光生物调节治疗/烧伤/瘙痒/伤口愈合/胶原蛋白/炎症/转录组/代谢Key words
photobiomodulation/burns/pruritus/wound healing/collagen/inflammation/transcriptome/metabolism分类
医药卫生引用本文复制引用
方科,李嘉龙,袁乐怡,王彤,余州,宋保强..基于808 nm波长的光生物治疗对深Ⅱ度烧伤大鼠瘙痒行为的研究[J].空军军医大学学报,2026,47(3):416-420,5.基金项目
国家自然科学基金面上项目(82372530) （82372530）
空军军医大学"临床医学+X"研究中心科研课题(LHJJ24WQ06) （LHJJ24WQ06）
