纤维素科学与技术2026，Vol.34Issue(1)：16-22,7.DOI:10.16561/j.cnki.xws.2026.01.06
普鲁士蓝@植酸-THPP纳米颗粒的光热和光动力抗菌效果
Photothermal and Photodynamic Antibacterial Effects of Phytic Acid@Prussian Blue-THPP Nanoparticles
何明阳 1靳焘2
作者信息
- 1. 中国科学院广州化学研究所,广东 广州 510650||中国科学院大学,北京 100049
- 2. 中国科学院广州化学研究所,广东 广州 510650||中国科学院大学,北京 100049||中国科学院新型特种精细化学品工程实验室,广东 广州 510650||国科广化韶关新材料研究院,广东 韶关 512400||国科广化精细化工孵化器(南雄)有限公司,广东 南雄 512400
- 折叠
摘要
Abstract
Addressing the public health challenges posed by bacterial infections and a wide range of microorganisms,this study synthesized a PB@PA-THPP NPs(PPTP)complex using Prussian blue(PB NPs)and tetra(m-hydroxyphenyl)porphyrin(THPP)as the core components and phytic acid(PA)as a bridge.Characterization analysis revealed that this material exhibits excellent near-infrared dual-light response:its temperature can rise sharply by more than 50℃under 808 nm laser light,demonstrating a significant photothermal effect;and it can effectively generate reactive oxygen species(ROS)under 650 nm excitation.In vitro experiments confirmed that the material has good biocompatibility.At a concentration of 0.5 mg/mL,it achieved a sterilization rate of over 99%against Staphylococcus aureus.This study successfully constructed a dual-mode nanoplatform,providing a new approach for clinical anti-infective therapy.关键词
卟啉/光动力疗法/光热疗法/普鲁士蓝/植酸/协同抗菌Key words
porphyrin/photodynamic therapy/photothermal/prussian blue/phytic acid/antibacterial分类
医药卫生引用本文复制引用
何明阳,靳焘..普鲁士蓝@植酸-THPP纳米颗粒的光热和光动力抗菌效果[J].纤维素科学与技术,2026,34(1):16-22,7.
