中风与神经疾病杂志2026，Vol.43Issue(3)：214-218,5.DOI:10.19845/j.cnki.zfysjjbzz.2026.0037
远端肢体缺血后适应治疗对急性缺血性脑卒中患者血清MMP-9、HIF-1α、IL-1β水平的影响
Effect of remote ischemic postconditioning on the serum levels of matrix metallopeptidase-9,hypoxia-inducible factor 1α,and interleukin-1β in patients with acute ischemic stroke
摘要
Abstract
Objective To investigate the effect of remote ischemic postconditioning(RIPostC)on the serum levels of matrix metallopeptidase-9(MMP-9),hypoxia-inducible factor 1α(HIF-1α),and interleukin-1β(IL-1β)in patients with acute ischemic stroke(AIS),and to further clarify the mechanism and clinical significance of RIPostC in the treat-ment of AIS.Methods A total of 115 AIS patients who were admitted to Suzhou First People's Hospital from May 2024 to February 2025 were enrolled,among whom 60 patients receiving conventional treatment were enrolled as control group,and 55 patients receiving RIPostC combined with conventional treatment for 7 consecutive days were enrolled as experi-mental group.ELISA was used to measure the serum levels of MMP-9,HIF-1α,and IL-1β,and National Institutes of Health Stroke Scale(NIHSS)was used to assess neurological function.Results After treatment,the experimental group had a significant increase in the level of HIF-1α(P<0.001)and significant reductions in the levels of MMP-9 and IL-1β(P<0.001).The experimental group had a significantly better NIHSS score than the control group(P<0.001).The in-crease in the serum level of HIF-1α could promote neurological function recovery.Conclusion RIPostC combined with conventional treatment can promote early neurological recovery in AIS patients,possibly by regulating the HIF-1α signal-ing pathway.关键词
远端肢体缺血后适应/急性缺血性脑卒中/血清基质金属蛋白酶-9/缺氧诱导因子-1α/白细胞介素-1βKey words
Remote ischemic postconditioning/Acute ischemic stroke/Serum matrix metalloproteinase-9/Hypoxia-inducible factor-1α/Interleukin-1β分类
医药卫生引用本文复制引用
蒋一飞,张方舟,蔡大棒,魏学文,齐素华..远端肢体缺血后适应治疗对急性缺血性脑卒中患者血清MMP-9、HIF-1α、IL-1β水平的影响[J].中风与神经疾病杂志,2026,43(3):214-218,5.基金项目
江苏省自然科学基金项目(BK20211348) （BK20211348）
徐州医科大学科技园创新创业项目(CXCYYB202415) （CXCYYB202415）
皖北卫生职业学院附属医院校级科学研究项目(WZK202406) （WZK202406）
