中风与神经疾病杂志2026，Vol.43Issue(3)：232-237,6.DOI:10.19845/j.cnki.zfysjjbzz.2026.0040
急性轻型非致残性缺血性脑卒中患者血压变异性与早期神经功能恶化的相关性分析
Association between blood pressure variability and early neurological deterioration in patients with acute mild non-disabling ischemic stroke
摘要
Abstract
Objective To investigate the association of blood pressure variability(BPV)with early neurological de-terioration(END)and prognosis in patients with acute mild non-disabling ischemic stroke.Methods The patients with acute mild non-disabling ischemic stroke who were admitted to Stroke Center of Affiliated Hospital of Inner Mongolia Uni-versity for Nationalities from January 2022 to August 2024 were enrolled,and according to the presence or absence of END,they were divided into non-END group and END group.General information,clinical data,and outcome measures were collected from all patients,and a binary logistic regression analysis was performed to determine independent risk fac-tors for END.According to the modified Rankin Scale(mRS)score,the patients were divided into good prognosis group(mRS score≤2 points)and poor prognosis group(mRS score>2 points),and a univariate logistic regression analysis was performed to investigate the influence of END on the 90-day neurological function prognosis of patients.Results A total of 61 patients were enrolled,with 14 patients in the END group and 47 patients in the non-END group.There was a signifi-cant difference in the coefficient of systolic pressure variation between the END group and the non-END group(P<0.05).The binary logistic regression analysis showed that systolic BPV(BPV>75%)was an independent risk factor for END(OR=14.000,95%CI 1.471-133.233,P=0.011).Compared with the non-END group,the END group had a significantly higher proportion of patients with a poor 90-day prognosis.Of all patients,there were 11 patients with poor prognosis and 50 patients with good prognosis on day 90.The uni-variate logistic regression analysis showed that END(OR=19.556,95%CI 4.038-94.696,P<0.001)was an independent risk factor for poor prognosis.Conclusion In patients with acute mild non-disabling ischemic stroke,the increase in coefficient of systolic pressure variation is an independent risk factor for END and affects the prognosis of neurological function on day 90.关键词
急性轻型缺血性脑卒中/非致残/早期神经功能恶化/血压变异/预后Key words
Acute mild ischemic stroke/Non-disabling/Early neurological deterioration/Blood pressure variability/Prognosis分类
医药卫生引用本文复制引用
马咏馨,杨璐,丛殿宝,张萌,秦贺,贾鸿博,李薇,张东威,徐耀铭..急性轻型非致残性缺血性脑卒中患者血压变异性与早期神经功能恶化的相关性分析[J].中风与神经疾病杂志,2026,43(3):232-237,6.基金项目
内蒙古自治区慢性病中(蒙)西医结合基础研究与转化创新中心开放课题(MDK2023001) （蒙）
内蒙古自治区重点研发和成果转化计划(2025YFSH0081) （2025YFSH0081）
