中草药2026，Vol.57Issue(6)：2016-2021,6.DOI:10.7501/j.issn.0253-2670.2026.06.002
云南藤黄中联苯类成分研究
Biphenyl compounds isolated from Garcinia yunnanensis
摘要
Abstract
Objective To investigate the biphenyl compounds in the ethyl acetate-soluble fraction of the twigs of Garcinia yunnanensis.Methods Based on the UV spectral characteristics absorption of biphenyl derivatives,targeted separation and purification were performed using various chromatography techniques,including silica gel column chromatography,Sephadex LH-20 gel column and semi-preparative HPLC.The structures of the isolated compounds were elucidated by means of physicochemical properties and spectral data of the monomer compounds,in combination with relevant literature.The anti-inflammatory activity of the new compound was evaluated by measuring its inhibition effect of nitric oxide(NO)production.Results Eight bipheny derivatives were obtained from the ethyl acetate fraction of G.yunnanensis,elucidated as(R)-5-(4-hydroxyphenyl)-2-(2-hydroxypropan-2-yl)-2,3-dihydrobenzofuran-7-ol(1),garcibiphenyl C(2),cylindrobiphenyl B(3),multibiphenyl C(4),doitungbiphenyls B(5),multiflorabiphenyl B(6),honokiol(7),and magnolol(8).Conclusion Compound 1 is a new compound named yunnabiphenyl A,while compounds 2-8 were reported from this plant for the first time.Compound 1 showed moderate anti-inflammatory activity,with a median inhibition concentration(IC50)value of 21.5 μmol/L.关键词
云南藤黄/联苯/抗炎/藤黄联苯A/和厚朴酚/厚朴酚/garcibiphenyl CKey words
Garcinia yunnanensis H.H.Hu/biphenyl/anti-inflammatory/yunnabiphenyl A/honokiol/magnolol/garcibiphenyl C分类
医药卫生引用本文复制引用
余越,陈煜,彭财英,梁永红,刘建群,舒积成..云南藤黄中联苯类成分研究[J].中草药,2026,57(6):2016-2021,6.基金项目
国家自然科学基金资助项目(82160660) （82160660）
江西省自然科学基金资助项目(20212ACB206006) （20212ACB206006）
江西中医药大学"1050"工程人才项目(5142001004)与创新团队(CXTD22015) （5142001004）
